Sensorimotor Interactions in Childhood Schizophrenia

儿童精神分裂症的感觉运动相互作用

• 批准号: 7154535
• 负责人: Tony W Wilson
• 金额: $ 2.35万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-26 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7154535
• 关键词: behavioral /social science research tag; body movement; brain electrical activity; brain interhemispheric activity; child psychology; clinical research; developmental psychology; fingers; human subject; magnetoencephalography; middle childhood (6-11); motor cortex; neural information processing; neuropathology; postdoctoral investigator; psychological tests; psychomotor function; schizophrenia; sensorimotor system; somesthetic sensory cortex

DESCRIPTION (provided by applicant): Soft neurological examinations in patients with psychotic illnesses have indicated salient sensorimotor abnormalities emerge early in life and are sustained through adulthood. The current proposal would investigate the neural basis of these sensorimotor aberrations in children with schizophrenia and matched controls. Using magnetoencephalography (MEG), the neuronal dynamics of sensorimotor processing will be probed during volitional finger movements and passive somatosensory stimulation. MEG analyses will utilize a beamforming approach that precisely images spatiotemporal activation patterns within a normalized space. In conjunction with the behavioral tasks, this imaging protocol will allow evaluation of interactive processes between motor and somatosensory cortices, as well as functional indices of each area in relative isolation. The results of this study could provide crucial data on the anomalous neural mechanisms underlying the sensorimotor abnormalities. Although these deficits are characteristic of schizophrenia patients at all ages, acquiring such knowledge in children will facilitate the identification of early neurophysiological markers of the illness, which could be especially important for earlier and more accurate diagnosis.

描述（由申请人提供）：对精神病患者的软神经学检查表明，明显的感觉运动异常在生命早期出现，并持续到成年。目前的提案将调查精神分裂症儿童和匹配对照儿童这些感觉运动异常的神经基础。使用脑磁图（MEG），将在手指意志运动和被动体感刺激期间探测感觉运动处理的神经元动力学。 MEG 分析将利用波束形成方法，对标准化空间内的时空激活模式进行精确成像。与行为任务相结合，该成像协议将允许评估运动皮层和体感皮层之间的交互过程，以及相对隔离的每个区域的功能指数。这项研究的结果可以提供关于感觉运动异常背后的异常神经机制的重要数据。尽管这些缺陷是所有年龄段的精神分裂症患者的特征，但在儿童中获得这些知识将有助于识别该疾病的早期神经生理学标志物，这对于更早和更准确的诊断尤其重要。

项目成果

Gamma-frequency neuronal activity is diminished in adults with attention-deficit/hyperactivity disorder: a pharmaco-MEG study.

患有注意力缺陷/多动障碍的成人的伽马频率神经元活动减少：一项药物 MEG 研究。

• DOI: 10.1177/0269881111430731
• 发表时间: 2012
• 期刊: Journal of psychopharmacology (Oxford, England)
• 作者: Wilson,TonyW;Wetzel,MartinW;White,MatthewL;Knott,NicholeL
• 通讯作者: Knott,NicholeL

Functional specialization within the supplementary motor area: a fNIRS study of bimanual coordination.

• DOI: 10.1016/j.neuroimage.2013.04.112
• 发表时间: 2014-01-15
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Wilson, Tony W.;Kurz, Max J.;Arpin, David J.
• 通讯作者: Arpin, David J.

Presence of strong harmonics during visual entrainment: a magnetoencephalography study.

• DOI: 10.1016/j.biopsycho.2012.04.008
• 发表时间: 2012-09
• 期刊: BIOLOGICAL PSYCHOLOGY
• 影响因子: 2.6
• 作者: Heinrichs-Graham, Elizabeth;Wilson, Tony W.
• 通讯作者: Wilson, Tony W.

Estimating the passage of minutes: deviant oscillatory frontal activity in medicated and unmedicated ADHD.

估计分钟的流逝：药物和未药物多动症中异常的振荡额叶活动。

• DOI: 10.1037/a0034032
• 发表时间: 2013
• 期刊: Neuropsychology
• 影响因子: 2.4
• 作者: Wilson,TonyW;Heinrichs-Graham,Elizabeth;White,MatthewL;Knott,NicholeL;Wetzel,MartinW
• 通讯作者: Wetzel,MartinW

Potential role for magnetoencephalography in distinguishing low- and high-grade gliomas: a preliminary study with histopathological confirmation.

脑磁图在区分低级别和高级别胶质瘤中的潜在作用：组织病理学证实的初步研究。

• DOI: 10.1093/neuonc/nos064
• 发表时间: 2012
• 期刊: Neuro-oncology
• 影响因子: 15.9
• 作者: Wilson,TonyW;Heinrichs-Graham,Elizabeth;Aizenberg,MicheleR
• 通讯作者: Aizenberg,MicheleR