Keystone Symposium on Lymphocyte Activation and Signaling

摘要 该提案要求支持一个名为淋巴细胞激活的关键研讨会， 信号，这将是在雪鸟，犹他州从2008年2月3日至8日举行。分化与激活 包括淋巴细胞在内的免疫细胞的活动受到一系列信号分子的严格控制。这些 包括感受外部刺激的受体;控制细胞内 生物化学信号;连接受体与细胞内效应物的衔接分子;和转录因子， 其他基因组修饰剂调节基因表达和结构。在过去的15年里， 我们对这些不同分子在正常细胞中的作用和调节的理解显著增加， 免疫反应最近，这些成分中的几种与人类疾病有关，如汽车， 免疫、免疫缺陷和淋巴恶性肿瘤。在这次研讨会上，我们邀请了杰出的 致力于免疫细胞信号传导前沿的研究人员。这些科学家将报告他们最 最近的调查结果，并提供了一个清晰的画面，该领域的发展方向。他们的研究结果对 将讨论对人类疾病的更好理解和可能的更好治疗。这尤其 会议将强调免疫细胞如何感知外部刺激，并通过细胞内信号 转导级联，介导适当的生物反应。它还将强调这一影响 对重大临床问题的知识，如自身免疫，免疫缺陷，肿瘤免疫， 移植和传染病。

ABSTRACT This proposal is to request support for a Keystone Symposia meeting entitled ¿Lymphocyte Activation and Signaling¿, which will be held in Snowbird, Utah from February 3 ¿ 8, 2008. The differentiation and activation of immune cells, including lymphocytes, is tightly controlled by a wide array of signaling molecules. These include receptors sensing external stimuli; kinases and phosphatases controlling the initiation of intracellular biochemical signals; adaptor molecules linking receptors to intracellular effectors; and transcription factors and other genomic modifiers regulating gene expression and structure. Over the past fifteen years, there has been a marked increase in our understanding of the roles and the regulation of these various molecules in a normal immune response. Recently, several of these components have been linked to human diseases such as auto- immunity, immunodeficiencies and lymphoid malignancies. In this symposium, we bring together distinguished researchers working at the cutting edge of immune cell signaling. These scientists will report on their most recent findings and provide a clear picture of where the field is going. The impact of their research findings on a better understanding and, possibly, better treatments of human diseases will be discussed. In particular, this meeting will highlight how immune cells can sense external stimuli and, through intracellular signal transduction cascades, mediate proper biological responses. It will also emphasize the impact of this knowledge on significant clinical problems such as auto-immunity, immunodeficiencies, tumor immunity, transplantation and infectious diseases.