Keystone Symposium on Lymphocyte Activation and Signaling

淋巴细胞激活和信号转导关键研讨会

• 批准号: 7325490
• 负责人: ANDREW D ROBERTSON
• 金额: $ 1万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-01-15 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7325490
• 关键词: Biochemical; Biological; Cells; Clinical; Communicable Diseases; Gene Expression; Genomics; Immune; Immune Cell Activation; Immune response; Immunity; Immunologic Deficiency Syndromes; Knowledge; Link; Lymphocyte; Lymphocyte Activation; Malignant lymphoid neoplasm; Mediating; Phosphoric Monoester Hydrolases; Phosphotransferases; Regulation; Reporting; Research; Research Personnel; Role; Scientist; Signal Transduction; Signaling Molecule; Stimulus; Structure; Transplantation; Tumor Immunity; Utah; Work; abstracting; human disease; receptor; response; symposium; transcription factor

ABSTRACT This proposal is to request support for a Keystone Symposia meeting entitled ¿Lymphocyte Activation and Signaling¿, which will be held in Snowbird, Utah from February 3 ¿ 8, 2008. The differentiation and activation of immune cells, including lymphocytes, is tightly controlled by a wide array of signaling molecules. These include receptors sensing external stimuli; kinases and phosphatases controlling the initiation of intracellular biochemical signals; adaptor molecules linking receptors to intracellular effectors; and transcription factors and other genomic modifiers regulating gene expression and structure. Over the past fifteen years, there has been a marked increase in our understanding of the roles and the regulation of these various molecules in a normal immune response. Recently, several of these components have been linked to human diseases such as auto- immunity, immunodeficiencies and lymphoid malignancies. In this symposium, we bring together distinguished researchers working at the cutting edge of immune cell signaling. These scientists will report on their most recent findings and provide a clear picture of where the field is going. The impact of their research findings on a better understanding and, possibly, better treatments of human diseases will be discussed. In particular, this meeting will highlight how immune cells can sense external stimuli and, through intracellular signal transduction cascades, mediate proper biological responses. It will also emphasize the impact of this knowledge on significant clinical problems such as auto-immunity, immunodeficiencies, tumor immunity, transplantation and infectious diseases.

摘要 这项提议是请求支持一次题为？淋巴细胞激活和 信号，将于2008年2月3日至8日在犹他州雪鸟举行。分化与激活 免疫细胞，包括淋巴细胞，受到广泛的信号分子的严格控制。这些 包括感知外部刺激的受体；控制细胞内启动的激酶和磷酸酶 生化信号；连接受体和细胞内效应器的适配器分子；以及转录因子和 其他调节基因表达和结构的基因组修饰物。在过去的15年里，有 我们对这些不同分子在正常情况下的作用和调节的理解显著增加 免疫反应。最近，这些成分中的几个与人类疾病有关，如汽车- 免疫、免疫缺陷和淋巴系统恶性肿瘤。在这次研讨会上，我们汇聚了杰出的 致力于免疫细胞信号传递前沿的研究人员。这些科学家将报告他们最多的 并为该领域的发展提供了一个清晰的图景。他们的研究成果对 我们将讨论如何更好地理解人类疾病，并可能对其进行更好的治疗。特别是，这一点 会议将强调免疫细胞如何通过细胞内信号感知外部刺激和 转导级联，调节适当的生物反应。它还将强调这一点的影响 了解重大临床问题，如自身免疫、免疫缺陷、肿瘤免疫、 移植和传染病。