Brain Therapeutics: Disruptive Technologies and Opportunities for Drug Development

摘要 请求支持题为大脑治疗：颠覆性的Keystone研讨会 药物开发的技术和机遇，由Maria-Jesse Blanco博士、Kalpana M。 Merchant和Mabel Loza García。会议将于2月在美国新墨西哥州圣达菲举行 2020年16日至19日。 中枢神经系统疾病是一种主要的未得到满足的医疗需求，与之相关的社会负担正在变得 由于人口结构的变化(例如，人口老龄化)而不可持续。为了应对这些负担，少校 政府和非营利性机构对基础研究和翻译研究进行了投资 世界范围内。然而，尽管做出了这些努力，制药公司和股票投资者仍认为 脑疗法是一个风险相对较大的投资领域。本次Keystone研讨会旨在 突出突破性技术和方法，以降低中枢神经系统靶向治疗的风险。更重要的是，通过 拟议议程和受邀演讲者，目的是展示跨学科的融合如何 知识和方法有可能克服中枢神经系统药物的当代挑战 发展。 这次会议的一个独特之处是，它汇集了来自一系列学科的科学家， 他们很少参加相同的会议，以创造一个可能导致颠覆性的环境 创新。特邀演讲者将提供一般概述以及深入的技术演示，以 让参与者参与许多主题，如疾病生物学-知情的目标选择，新的药物 化学方法、生物标记物和临床试验设计。基因组学等技术的进步， 成像和大脑交付将在整个过程中得到强调。节目的演讲者代表公众和 私营部门、年轻和成熟的科学家以及世界各地的地理。本次大会致力于创造 一个跨学科的环境，其中将形成新的协作，这种协作可能会在 会议本身，并帮助解决中枢神经系统疾病未得到满足的医疗需求。最后，这次会议是 与Keystone研讨会的脑液流动和功能：淋巴管，G淋巴管配对 脉络丛。这项研究的目标是激发基于脑脊液的跨学科思考。 药物疗法。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Brain Therapeutics: Disruptive Technologies and Opportunities for Drug Development, organized by Drs. Maria-Jesus Blanco, Kalpana M. Merchant and Mabel Loza García. The conference will be held in Santa Fe, New Mexico USA from February 16-19, 2020. CNS disorders represent a major unmet medical need with an associated societal burden that is becoming unsustainable due to changing demographics (e.g., aging population). In response to these burdens, major investments in basic and translational research have been made by government and non-profit institutions world-wide. However, despite these efforts, pharmaceutical companies and equity investors continue to view brain therapeutics as a relatively risky area of investment. This Keystone Symposia conference aims to highlight breakthrough technologies and approaches to de-risk CNS-targeted therapies. More importantly, with the proposed agenda and invited speakers, an aim is to demonstrate how that integration of cross-disciplinary knowledge and approaches has the potential to overcome the contemporary challenges of CNS drug development. One of the unique features of this conference is that it brings together scientists from a range of disciplines, who rarely participate in the same meetings, in order to create an environment that can lead to disruptive innovation. Invited speakers will provide a general overview, as well as in-depth technical presentations, to engage the participants in numerous topics, such as disease biology-informed target selection, novel medicinal chemistry approaches, biomarkers, and clinical trial designs. Advances in technologies such as genomics, imaging and brain delivery will be highlighted throughout. The speakers on the program represent public and private sectors, young and established scientists and world-wide geography. This conference aspires to create an interdisciplinary environment where new collaborations will form that could continue well beyond the conference itself and help address the unmet medical need of CNS disorders. Finally, this meeting is being paired with the Keystone Symposia conference on Cerebral Fluid Flow and Function: Lymphatics, Glymphatics and the Choroid Plexus. The goal of this paring is to stimulate cross-disciplinary thinking about CSF-based medicinal therapies.