Brain Therapeutics: Disruptive Technologies and Opportunities for Drug Development

脑治疗：药物开发的颠覆性技术和机遇

• 批准号: 9913762
• 负责人: Thale Cross Jarvis
• 金额: $ 1.29万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-15 至 2020-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9913762
• 关键词: Address; Area; Basic Science; Biological Markers; Biology; Brain; Brain Diseases; Central Nervous System Diseases; Cerebrum; Clinical Investigator; Clinical Trials Design; Collaborations; Discipline; Disease; Educational workshop; Environment; Future; Genomics; Geography; Goals; Government; Health; Human; Image; Industrialization; Institution; Investments; Knowledge; Lead; Learning; Lymphatic; Medical; Methodology; New Mexico; Outcome; Participant; Pharmaceutical Chemistry; Pharmacologic Substance; Private Sector; Public Sector; Research; Research Personnel; Risk; Scientist; Speed; Structure of choroid plexus; Technology; Therapeutic; Thinking; Translational Research; Translations; Work; aging population; base; clinical implementation; clinical practice; collaborative environment; combat; demographics; digital; drug development; fluid flow; functional group; glymphatic system; innovation; interest; meetings; new technology; novel; novel strategies; posters; pre-clinical; programs; response; symposium; synergism; targeted treatment; translational approach

ABSTRACT Support is requested for a Keystone Symposia conference entitled Brain Therapeutics: Disruptive Technologies and Opportunities for Drug Development, organized by Drs. Maria-Jesus Blanco, Kalpana M. Merchant and Mabel Loza García. The conference will be held in Santa Fe, New Mexico USA from February 16-19, 2020. CNS disorders represent a major unmet medical need with an associated societal burden that is becoming unsustainable due to changing demographics (e.g., aging population). In response to these burdens, major investments in basic and translational research have been made by government and non-profit institutions world-wide. However, despite these efforts, pharmaceutical companies and equity investors continue to view brain therapeutics as a relatively risky area of investment. This Keystone Symposia conference aims to highlight breakthrough technologies and approaches to de-risk CNS-targeted therapies. More importantly, with the proposed agenda and invited speakers, an aim is to demonstrate how that integration of cross-disciplinary knowledge and approaches has the potential to overcome the contemporary challenges of CNS drug development. One of the unique features of this conference is that it brings together scientists from a range of disciplines, who rarely participate in the same meetings, in order to create an environment that can lead to disruptive innovation. Invited speakers will provide a general overview, as well as in-depth technical presentations, to engage the participants in numerous topics, such as disease biology-informed target selection, novel medicinal chemistry approaches, biomarkers, and clinical trial designs. Advances in technologies such as genomics, imaging and brain delivery will be highlighted throughout. The speakers on the program represent public and private sectors, young and established scientists and world-wide geography. This conference aspires to create an interdisciplinary environment where new collaborations will form that could continue well beyond the conference itself and help address the unmet medical need of CNS disorders. Finally, this meeting is being paired with the Keystone Symposia conference on Cerebral Fluid Flow and Function: Lymphatics, Glymphatics and the Choroid Plexus. The goal of this paring is to stimulate cross-disciplinary thinking about CSF-based medicinal therapies.

摘要 请求支持一次题为“脑治疗：破坏性”的Keystone研讨会 药物开发的技术和机会，由Maria-Jesus布兰科、Kalpana M. Merchant和美宝Loza Garcia会议将于二月在美国新墨西哥州圣达菲举行 2020年16-19日。 CNS疾病是一种主要的未满足的医疗需求，伴随着相关的社会负担， 由于不断变化的人口统计数据（例如，人口老龄化）。面对这些挑战，少校 政府和非营利机构对基础研究和转化研究进行了投资 世界范围内。然而，尽管做出了这些努力，制药公司和股票投资者继续认为， 大脑治疗是一个相对风险较大的投资领域。本次Keystone研讨会旨在 突出了突破性技术和方法，以降低CNS靶向治疗的风险。更重要的是，随着 拟议的议程和邀请的发言者，目的是展示如何整合跨学科 知识和方法有可能克服CNS药物的当代挑战 发展 这次会议的一个独特之处是，它汇集了来自一系列学科的科学家， 他们很少参加相同的会议，以创造一个可能导致破坏性的环境 创新特邀演讲者将提供一个总体概述，以及深入的技术演示，以 让参与者参与许多主题，例如疾病生物学信息靶标选择，新的药物 化学方法、生物标志物和临床试验设计。基因组学等技术的进步， 成像和大脑传递将贯穿始终。节目中的发言人代表公众， 私营部门、年轻和成熟的科学家以及世界地理。本次会议旨在创造 一个跨学科的环境，新的合作将形成，并可能在未来继续下去 会议本身，并帮助解决未满足的医疗需求的中枢神经系统疾病。最后，这次会议正在 与脑液流动和功能的基石研讨会：淋巴学，神经病学配对 和脉络丛这种配对的目标是激发对基于CSF的 药物治疗