Heart Failure: All Cells Considered

心力衰竭：考虑所有细胞

• 批准号: 10681061
• 负责人: TERRY L. SHEPPARD
• 金额: $ 1万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10681061
• 关键词: Acceleration; Address; Adopted; Area; Basic Science; Cardiac; Cardiovascular system; Career Mobility; Cells; Clinical; Collaborations; Development; Disease; EFRAC; Education; Educational workshop; Environment; Event; Fibrosis; Future; Genetic; Growth; Heart; Heart failure; Heterogeneity; Industrialization; Inflammation; Knowledge; Learning; Medicine; Metabolism; Methodology; Methods; Molecular; Morbidity - disease rate; Myocardial; New Mexico; Outcome; Oxygen; Participant; Prevalence; Process; Pulmonary Hypertension; Pump; Research; Research Personnel; Scientist; Sex Differences; Signal Pathway; Signal Transduction; Technology; Therapeutic; Translating; Translations; Work; career; clinical implementation; clinical practice; ethnic disparity; experimental study; health disparity; hospitalization rates; improved; interest; mortality; multidisciplinary; next generation; novel; novel strategies; posters; preservation; prevent; programs; racial disparity; symposium; translational therapeutics

ABSTRACT Support is requested for a Keystone Symposia conference entitled Heart Failure: All Cells Considered, organized by Drs. Merry Lindsey, Crystal Ripplinger and Zamaneh Kassiri. The conference will be held in Santa Fe, New Mexico from June 25 - 28, 2023. Heart failure has conventionally been defined as the inability of the heart to pump sufficiently to meet the needs of the body for oxygen. Understanding the cell signaling pathways and molecular mechanisms that trigger heart failure is a major challenge in cardiovascular medicine. Consequently, there is a strong need to better understand the cellular and molecular mechanisms that drive the development of heart failure. This conference program will address knowledge gaps to illuminate processes such as cardiac remodeling, inflammation, fibrosis, and cell heterogeneity. Invited speakers will share results from their current research and disseminate new knowledge about heart failure with a focus on cell and molecular signaling. The program also includes sessions on the current limitations in therapeutic translation, as well as cell to cell crosstalk. Moreover, there exists significant sex differences in prevalence, presentation, and treatment of both heart failure with reduced ejection fraction (HFrEF) and those with preserved ejection fraction (HFpEF). Sex differences and racial and ethnic disparities will be further explored through a health disparities workshop. Finally, this conference will be paired with the Keystone Symposia conference on Pulmonary Hypertension: State of the Art and Therapeutic Opportunities. This pairing will cover important subjects of scientific interest to both fields, such as the intersection between myocardial metabolism and genetics. Participants of both conferences will be able to network and interact through shared mealtimes, poster sessions, and workshops. Overall, attendees will leave this conference with clear ideas on the most critical experiments needed to accelerate the field forward.

摘要 要求支持一个题为“心力衰竭：考虑到所有细胞”的基石专题讨论会， 由梅丽·林赛、克里斯托·里普林格和扎马内·卡西里博士组织。会议将于 2023年6月25日至28日，新墨西哥州圣达菲。 心力衰竭通常被定义为心脏无法充分泵血以满足需要 身体的氧气。了解细胞信号通路和分子机制，触发 心力衰竭是心血管医学中的主要挑战。因此，迫切需要更好地 了解推动心力衰竭发展的细胞和分子机制。这次会议 该计划将解决知识差距，以阐明心脏重塑，炎症， 纤维化和细胞异质性。特邀演讲者将分享他们目前的研究成果，并传播 关于心力衰竭的新知识，重点是细胞和分子信号传导。该计划还包括 关于目前治疗翻译的局限性以及细胞间串扰的会议。而且 在心力衰竭的患病率、表现和治疗方面存在显著的性别差异， 射血分数（HFrEF）和射血分数保留（HFpEF）的患者。性别差异和种族差异， 将通过一个健康差异讲习班进一步探讨族裔差异问题。最后，本次会议将在 与肺动脉高压的Keystone研讨会：最新技术和治疗 机会这一配对将涵盖两个领域的重要科学兴趣，如 心肌代谢和遗传学的交叉点。两个会议的与会者将能够 通过共享用餐时间，海报会议和研讨会进行网络和互动。总的来说，与会者将离开 这次会议对加速该领域发展所需的最关键的实验提出了明确的想法。