Innate Immune Memory: From Evolutionary Roots to Human Disease

摘要 请求支持题为《先天免疫记忆：来自进化》的Keystone研讨会 人类疾病的根源，由Mihai G.Netea博士、Shabaana A.Khader和Triantafyllos Chavakis博士组织。 大会将于2022年3月6日至9日在加拿大艾伯塔省班夫举行。 先天免疫反应的记忆特征(也称为训练免疫)已被认识到 直到最近，大量研究表明，它们对长期广泛的预防疾病的重要性 感染。先天免疫记忆已被证明在植物和 无脊椎动物，但也在脊椎动物的宿主防御中发挥重要作用，哺乳动物在 很特别。在人类中，先天免疫记忆对宿主防御感染很重要，而且可能 增强抗肿瘤免疫，但也可在炎症和自身免疫发病机制中发挥作用 疾病。新型免疫疗法的出现正在对疾病的结局产生深远的影响 在癌症、自身免疫性疾病甚至严重感染等几种主要病理中。然而， 免疫治疗研究主要集中在针对适应性免疫细胞(例如，检查点 抑制剂、CAR-T细胞、单抗)，对先天免疫细胞的关注相对较少。这 会议打算通过作为一个国际论坛来改变这一点，以强调人的先天性免疫过程 与免疫疗法相关。这次会议是一个独特的平台，来自几个重要的 领域(免疫学、进化生物学、癌症生物学、传染病和生理学、临床和 健康科学)将能够互动和交流想法、方法并建立合作：这是正在出现的 作为免疫学中最令人兴奋的领域之一，拟议的Keystone研讨会有机会 有力地推动了这一新颖的研究领域。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Innate Immune Memory: From Evolutionary Roots to Human Disease, organized by Drs. Mihai G. Netea, Shabaana A. Khader and Triantafyllos Chavakis. The conference will be held in Banff, Alberta, Canada from March 6-9, 2022. Memory characteristics of innate immune responses (also termed ‘trained immunity’) have been recognized only recently, with a multitude of studies demonstrating their importance for long-term broad protection against infections. Innate immune memory has been demonstrated to have deep evolutionary roots in plants and invertebrates, but also plays an important role in the host defense of vertebrates in general, and mammals in particular. In humans, innate immune memory is important for host defense against infections, and may enhance anti-tumor immunity, but can also contribute to pathogenesis in inflammatory and autoimmune diseases. The emergence of novel types of immunotherapy is having a profound impact on disease outcomes in several major pathologies such as cancer, autoimmune diseases and even severe infections. However, the immunotherapeutic research has largely focused on targeting adaptive immune cells (e.g., checkpoint inhibitors, CAR-T cells, monoclonal antibodies), with relatively little attention to innate immune cells. This conference intends to change this by serving as an international forum to highlight innate immune processes of relevance to immunotherapies. This meeting is a unique platform, in which researchers from several important fields (immunology, evolutionary biology, cancer biology, infectious diseases and physiology, clinical and health sciences) will be able to interact and exchange ideas, methods and build collaborations: this is emerging as one of the most exciting areas in immunology, and the proposed Keystone Symposium has the chance to give a strong impetus to this novel field of research.