Innate Immune Memory: From Evolutionary Roots to Human Disease

摘要 请求支持Keystone研讨会会议，题为先天免疫记忆：从进化 人类疾病的根源，由Mihai G.沙巴阿纳·内泰亚卡德尔和特里亚塔菲洛斯·查瓦基斯 会议将于2022年3月6日至9日在加拿大阿尔伯塔省班夫举行。 先天免疫反应的记忆特征（也称为“训练免疫”）已经被公认 直到最近，大量的研究证明了它们对长期广泛保护的重要性， 感染.先天免疫记忆已被证明在植物中具有深刻的进化根源， 无脊椎动物，而且在一般脊椎动物和哺乳动物的宿主防御中也起着重要作用， 特别的。在人类中，先天免疫记忆对于宿主防御感染很重要，并且可能 增强抗肿瘤免疫，但也可能有助于炎症和自身免疫性疾病的发病机制 疾病新型免疫疗法的出现对疾病的结果产生了深远的影响 在几种主要的病理学中，例如癌症、自身免疫性疾病和甚至严重的感染。但 免疫学研究主要集中在靶向适应性免疫细胞（例如，检查点 抑制剂、CAR-T细胞、单克隆抗体），对先天免疫细胞的关注相对较少。这 会议打算改变这一点，作为一个国际论坛，以突出先天免疫过程， 与免疫疗法的相关性。这次会议是一个独特的平台，来自几个重要国家的研究人员 领域（免疫学，进化生物学，癌症生物学，传染病和生理学，临床和 健康科学）将能够互动和交流思想，方法和建立合作：这是新兴的 作为免疫学中最令人兴奋的领域之一，拟议的Keystone研讨会有机会 为这一新的研究领域提供了强大的动力。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Innate Immune Memory: From Evolutionary Roots to Human Disease, organized by Drs. Mihai G. Netea, Shabaana A. Khader and Triantafyllos Chavakis. The conference will be held in Banff, Alberta, Canada from March 6-9, 2022. Memory characteristics of innate immune responses (also termed ‘trained immunity’) have been recognized only recently, with a multitude of studies demonstrating their importance for long-term broad protection against infections. Innate immune memory has been demonstrated to have deep evolutionary roots in plants and invertebrates, but also plays an important role in the host defense of vertebrates in general, and mammals in particular. In humans, innate immune memory is important for host defense against infections, and may enhance anti-tumor immunity, but can also contribute to pathogenesis in inflammatory and autoimmune diseases. The emergence of novel types of immunotherapy is having a profound impact on disease outcomes in several major pathologies such as cancer, autoimmune diseases and even severe infections. However, the immunotherapeutic research has largely focused on targeting adaptive immune cells (e.g., checkpoint inhibitors, CAR-T cells, monoclonal antibodies), with relatively little attention to innate immune cells. This conference intends to change this by serving as an international forum to highlight innate immune processes of relevance to immunotherapies. This meeting is a unique platform, in which researchers from several important fields (immunology, evolutionary biology, cancer biology, infectious diseases and physiology, clinical and health sciences) will be able to interact and exchange ideas, methods and build collaborations: this is emerging as one of the most exciting areas in immunology, and the proposed Keystone Symposium has the chance to give a strong impetus to this novel field of research.