Myeloid Cells: From Birth to Immunity and Disease

摘要 请求支持题为“髓样细胞：从出生到免疫”的Keystone研讨会。 疾病，由Venizelos Papayannopoulos博士、Claudia Jakubzick博士和Martin Guilliams博士组织。这个 会议将于2022年3月6日至9日在加拿大艾伯塔省班夫举行。 髓系细胞是先天免疫系统的主力。他们对于生存和发挥核心作用是必不可少的 在人类疾病中扮演的角色。最近的发展揭示了髓系细胞在组织协调中的新角色 免疫防御、组织动态平衡、代谢状态和神经功能。这些函数是 由复杂的细胞信号通路和与其他宿主细胞相互作用的迷人网络调控 微生物和微生物群。髓系细胞也可以解除管制，以促进炎症、代谢、 退行性和神经系统疾病，并被病原体和肿瘤细胞劫持以促进感染和 癌症。会议将探讨髓系细胞的不同生物学作用，并强调 定义髓系细胞的身份。这次会议的一个独特之处是，将把重点放在项目上 髓系细胞分化是如何通过生活方式、免疫学和代谢信号来塑造细胞功能的。 该计划还将涵盖髓系细胞与其他免疫细胞、肿瘤、间质之间的相互作用 和神经元隔间。这次会议将突出我们对 调节髓系细胞反应的细胞生物学、代谢和信号机制。与会者将离开 这次会议全面阐述了髓系细胞分化和细胞调节如何影响 在动态平衡和疾病中的作用。这一观点将促进研究领域和 确定令人振奋的未来研究方向。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Myeloid Cells: From Birth to Immunity and Disease, organized by Drs. Venizelos Papayannopoulos, Claudia Jakubzick and Martin Guilliams. The conference will be held in Banff, Alberta, Canada from March 6 - 9, 2022. Myeloid cells are the workhorses of the innate immune system. They are essential for survival and play central roles in human disease. Recent developments have uncovered novel roles for myeloid cells in orchestrating immune defense, tissue homeostasis, metabolic state, and neurological function. These functions are regulated by complex cellular signaling pathways and a fascinating network of interactions with other host cells and microbes and the microbiome. Myeloid cells can also be deregulated to promote inflammatory, metabolic, degenerative and neurological conditions and hijacked by pathogens and tumor cells to promote infection and cancer. The conference will explore the diverse biological roles of myeloid cells and highlight the pathways that define myeloid cell identity. One unique aspect of this conference is that one focus on the program will be on how myeloid cell differentiation is tuned by lifestyle, immunological and metabolic cues to shape cell function. The program will also cover the interactions between myeloid cells and other immune cells, tumors, the stroma and neuronal compartments. The conference will highlight the latest developments in our understanding of the cell biological, metabolic and signaling mechanisms that regulate myeloid cell responses. Attendees will leave the conference with a comprehensive view of how myeloid cell differentiation and cellular regulation impacts function in homeostasis and disease. This perspective will promote synergy across research areas and identify exciting future research directions.