Immunity and Aging

免疫与衰老

• 批准号: 10753410
• 负责人: TERRY L. SHEPPARD
• 金额: $ 1.92万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10753410
• 关键词: Adaptive Immune System; Address; Aging; Area; Artificial Intelligence; Basic Science; Big Data; Biological; Biology of Aging; Biotechnology; COVID-19 pandemic; Canada; Chronic Disease; Collaborations; Communicable Diseases; Communities; Development; Disease; Distant; Drug Industry; Educational workshop; Elderly; Emerging Technologies; Fertilization; Functional disorder; Goals; Health; Homeostasis; Human; Human Biology; Immune; Immune Targeting; Immune response; Immune system; Immunity; Immunology; Inflammaging; Inflammation; Innate Immune System; International; Interruption; Knowledge; Learning; Longevity; Mentors; Metabolism; Methodology; Neurobiology; Normal tissue morphology; Outcome; Pathology; Predisposition; Process; Research; Research Personnel; Risk Factors; Science; Scientist; Speed; Tissues; Touch sensation; Translations; Vaccines; age effect; age related; body system; clinical practice; combat; design; frontier; functional decline; healthspan; hematopoietic stem cell aging; immune activation; immune function; improved; insight; interest; mortality; multidisciplinary; novel therapeutics; posters; programs; prospective; single cell sequencing; stem cell biology; stem cells; symposium; therapy development

ABSTRACT Support is requested for a Keystone Symposia conference entitled Immunity and Aging, organized by Drs. Danica Chen, Sun Hur and Joan Mannick. The conference will be held in Whistler, Canada from October 1-4, 2023. Aging is the single largest risk factor for a wide spectrum of chronic diseases and mortality. An outstanding question in human biology is how we lose the ability to maintain homeostasis and become susceptible to diseases and mortality. However, as groundbreaking research has emerged over the past decade, there is evidence that the decline in function of aging organ systems is caused by a discreet number of biological mechanisms. For instance, recent single cell sequencing studies suggest that one mechanism contributing to dysfunction of the aging immune system is a widespread basal activation of immune cells across tissues. Additionally, dysfunction of the aging immune system results in suboptimal immune responses to vaccines and infectious diseases in older adults, as has been highlighted recently by the COVID-19 pandemic. This Keystone Symposia conference will provide an international venue for researchers to discuss these timely topics, specifically, to understand how the immune system becomes dysregulated during the aging process and how the aging immune system impinges upon the tissue functions, organismal health span and survival. This program touches on questions including: (i) how aging of hematopoietic stem cells contribute to dysfunction of the aging immune system and impacts distant tissues and (ii) how age-related changes in innate and adaptive immune function compromise immunity. Other sessions will discuss the origins of aging-associated inflammation and how inflammation impacts tissue functions and contributes to aging-related conditions. The conference will bring together investigators from multiple fields—immunology, aging, metabolism, stem cell biology and neurobiology—to advance the frontier of immunity and aging.

摘要 要求为由Dr.S. Danica Chen，Sun Hur和Joan Mannick。会议将于10月1日至4日在加拿大惠斯勒举行， 2023. 老龄化是一系列慢性病和死亡的最大风险因素。一位杰出 人类生物学中的一个问题是，我们如何失去维持体内平衡的能力， 疾病和死亡率。然而，随着过去十年来突破性研究的出现， 有证据表明，衰老器官系统功能的下降是由一些生物学因素引起的。 机制等例如，最近的单细胞测序研究表明， 衰老免疫系统的功能障碍是免疫细胞在组织中广泛的基础活化。 此外，衰老免疫系统的功能障碍导致对疫苗的次优免疫应答， 老年人感染性疾病，最近的COVID-19疫情凸显了这一点。这个Keystone 研讨会将为研究人员提供一个讨论这些及时主题的国际场所， 特别是，了解免疫系统在衰老过程中如何变得失调， 老化的免疫系统影响组织功能、有机体健康寿命和存活。这个程序 涉及的问题包括：（i）造血干细胞的老化如何导致衰老功能障碍 免疫系统和影响遥远的组织和（ii）如何与年龄有关的变化，先天性和适应性免疫 功能损害免疫力。其他会议将讨论与衰老相关的炎症的起源， 炎症如何影响组织功能并导致衰老相关疾病。会议将带来 来自多个领域的研究人员-免疫学，衰老，代谢，干细胞生物学和 神经生物学-推进免疫和衰老的前沿。