Hydrogen Bonds as Control Elements to Direct the Selectivity of Transition Metal-Catalyzed Reactions

该项目旨在开发催化剂，使其能够同时控制化学反应发生的分子位置和反应过程中形成的立体中心的绝对构型。氢键用于将底物与过渡金属的手性配体预配位。因此，催化活性中心的空间接近性决定了转化的区域选择性，而对映体选择性则由非共价相互作用决定。将研究六个关键反应，其中类氧、类氮或类碳物质攻击双键或碳氢键。单个基板与过渡金属中心之间的理想距离有待优化。研究这些方法在天然产物合成中的应用，是本项目的补充。

The project aims at the development of catalysts, which allow for a simultaneous control of the molecular position, at which a chemical reaction takes place, and of the absolute configuration of the stereogenic center, which is formed during the reaction. Hydrogen bonds are employed to pre-coordinate a substrate to the chiral ligand of a transition metal. As a result the spatial proximity of the catalytically active center determines the regioselectivity of the transformation while the enantioselectivity is determined by the non-covalent interaction. Six key reactions are to be studied in which oxenoid, nitrenoid or carbenoid species attack either a double bond or a C-H bond. Ideal distances between the individual substrates and the transition metal center are to be optimized. Studies to possible application of the methods in natural product synthesis supplement the Project.