The molecular basis of association mechanism between Alzheimer's disease and tooth loss

为了阐明牙缺失与阿尔茨海默病之间的关系，我们使用阿尔茨海默病模型小鼠比较了拔牙组和牙齿完整组。因此，我们发现牙齿脱落并不影响Aβ的积累。但拔牙组的锥体细胞数较完整组减少。行为测试结果显示，牙齿缺失会降低学习和记忆能力。我们认为牙齿缺失可能通过另一条已知的淀粉样蛋白级联反应途径影响AD的发病机制或发病。

To elucidate the association between tooth loss and Alzheimer ’ s disease, we compared tooth extracted group with tooth intact group using Alzheimer ’ s model mice. As a result, we found that tooth loss did not influence the accumulation of Aβ. However, the number of pyramidal cell of tooth extracted group is decreased compared with tooth intact group. And, the results of behavioral test revealed that tooth loss deteriorates the learning and memory ability. We could suggest that tooth loss affect the AD pathogenesis or AD onset through another pathway of well-known amyloid cascade.