Cancer Neoantigens, Vaccines and Viruses

摘要 请求为题为癌症新抗原、疫苗和 病毒，由凯瑟琳·J·吴博士、罗伯特·D·施赖伯博士和科内利斯·J·M·梅里夫博士组织。会议将于 将于2021年6月27日至7月1日在加拿大卑诗省温哥华举行。 癌症免疫治疗的进展正在迅速改变各种癌症的治疗格局，但 该领域的关键挑战是了解我们如何更好地将T细胞驱动到肿瘤中，从而使 它们可用于提高有效的抗肿瘤反应。病毒和癌症免疫领域共享 从每个领域学到的许多相似之处和见解可以扩展我们关于如何解决 这项挑战。癌症疫苗是一种有价值的免疫治疗方式，能够扩大 肿瘤特异性T细胞谱系，并有可能与补体有效结合 治疗方法。这一会议计划旨在突出最近令人兴奋的临床和 科学进展，包括识别新的抗原靶点，对肿瘤如何 微环境受到免疫调节和肿瘤免疫治疗的调节，而肿瘤免疫治疗的发展 新的治疗方法。共同分享从跨学科获得的知识 这次会议的互动有望为考虑设计的新方法开辟道路 更有效的癌症免疫疗法。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Cancer Neoantigens, Vaccines and Viruses, organized by Drs. Catherine J. Wu, Robert D. Schreiber and Cornelis J.M. Melief. The conference will be held in Vancouver, BC Canada from June 27- July 1, 2021. Advances in cancer immunotherapy are rapidly transforming the treatment landscape across cancers, but a critical challenge in the field is understanding how we can better drive T cells into tumors, and hence make them available for mounting productive anti-tumor responses. The fields of viral and cancer immunity share many parallels, and insights learned from each area can expand our collective knowledge of how to address this challenge. Cancer vaccines are a valuable immunotherapeutic modality, capable of expanding the repertoire of tumor-specific T cells and have the potential to be productively combined with complementary therapeutic approaches. This conference program was designed to highlight the exciting recent clinical and scientific advances, including the identification of novel antigen targets, new understanding of how the tumor microenvironment is immunoregulated and modulated by cancer immunotherapies, and the development of novel therapeutic approaches. Together, the collective shared knowledge gained from interdisciplinary interactions from this meeting promise to open the path for consideration of novel approaches for the design of more effective cancer immunotherapies.