REGIONAL CEREBRAL CIRCULATION AND METABOLISM

以该项目为代表的一项长期研究计划， 多年来一直致力于开发、验证和 局部生理和病理变化率测量方法的应用 生物化学过程中的离散功能和结构组件 的大脑。这些方法被设计用于意识实验室 动物，并在某些情况下最终适用于人与PET。的 [C（14）]-碘安替比林法测定局部脑血流量 [C（14）]-脱氧葡萄糖法测定脑局部葡萄糖 利用率是该研究项目成果的实例。是 值得注意的是，唯一的标准，常规使用和接受的定量 用于人体的PET方法是这两种方法的衍生物。 该项目最近的工作包括将这些方法应用于 各种生理、生化和药理学状态的研究 和有限数量的病理状态。过去的主要努力 多年来，啤酒一直致力于1）脱氧葡萄糖方法的改进， 使其更适用于严重的病理状态， 该方法的基本要求适用于生理 国家可能不适用; 2）开发连续双标签程序 用它来研究控制和改变行为状态， 动物在一次实验中

A long range program of research represented by this project has for a number of years been directed at the development, validation, and applications of methods for measurement of local rates of physiological and biochemical processes in the discrete functional and structural components of the brain. These methods are designed to be used in conscious laboratory animals and in some cases eventually adapted for use in man with PET. The [C(14)]-iodoantipyrine method for measuring local cerebral blood flow and the [C(14)]-deoxyglucose method for measuring local cerebral glucose utilization are examples of outcomes of this research program. It is noteworthy that the only standard, routinely used and accepted quantitative methods for use in man with PET are derivatives of these two methods. Recent work on this project has included applications of these methods to studies of various physiological, biochemical, and pharmacological states and a limited number of pathological states. The main efforts this past year have beer directed toward 1) refinement of the deoxyglucose method to make it more applicable to severe pathological states when some of the basic requirements of the method that are appropriate to physiological states may not apply; 2) development of a sequential double label procedure with which to study control and altered behavioral states in the same animal during one experimental session.