Toxicity Of Lead In Children--Clinical Trial

琥珀酸盐是一种降低血铅浓度的口服螯合剂，在一项随机临床试验中，血铅浓度为每分升20至44微克的儿童在2岁左右时服用琥珀酸盐或安慰剂，随后进行认知和行为测试。我们之前报道过，尽管在治疗期间血铅水平较低，但服用琥珀酸盐的儿童在5岁或7岁时的测试分数与服用安慰剂的儿童没有什么不同。我们已经安排CDC对该项目收集的血液样本进行甲基汞、无机汞和镉的分析，这将允许在不招募任何新受试者或收集任何样本的情况下，对这些化合物进行二聚体螯合的随机试验。琥珀酸盐似乎不是一种有效的汞或镉螯合剂。汞和镉都与认知或行为测试成绩无关，镉也与血压无关

In a randomized clinical trial of succimer, an oral chelating agent that lowers blood lead concentration, children with blood leads of 20 to 44 micrograms per deciliter were given succimer or placebo when they were about 2 years old and followed with cognitive and behavioral testing. We reported previously that, despite lower blood lead levels during treatment, children given succimer had test scores that were no different from those of children given placebo at ages five or seven years. We have arranged with CDC to analyze blood samples collected in this project for methyl mercury, inorganic mercury, and cadmium, which will allowed a randomized trial of succimer for chelation of these compounds without enrolling any new subjects or collecting any specimens. Succimer does not appear to be an efficacious chelating agent for mercury or cadmium. Neither mercury nor cadmium is associated with cognitive or behavioral test scores, and cadmium is not associated with blood pressure