Center for Molecular, Cellular, and Translational Immunology

描述(申请人提供)：基于最初的10年奖的成功，此次Cobre续签申请的最终目标是在达特茅斯完成一个国家认可的分子、细胞和翻译免疫研究中心的建立，并在五年内将这个Cobre免疫研究中心(Cobre-CIR)转变为一个以基础设施为基础的、独立的(来自Cobre基金)、可持续的中心。在长期免疫学计划的基础上，这项计划利用了达特茅斯医学院(DMS)和达特茅斯希区柯克医学中心(DHMC)高度互动的核心教员，目前已得到Cobre的大力支持。随着研究人员基础的扩大，第三阶段Cobre奖将提供资源，以建立维持Cobre-CIR所需的基础设施，进一步发展该计划，并促进跨学科的基础科学到转化性免疫学研究。这一基础设施将包括继续发展我们的免疫学教员，特别是那些以前得到Cobre支持的研究人员；Cobre核心的扩展，以及它们与DMS/DHMC现有的补充核心和共享服务的全面整合，特别是Norris Cotton癌症中心和达特茅斯大学和佛蒙特州大学的其他免疫学和“肺生物学”Cobres中心；以及旨在进行有指导、协作和/或翻译/人类系统研究的增强试点项目计划。加上DMS/DHMC的实质性机构承诺，有信心进一步发展已经由Cobre机制扩大和成熟的强大现有调查人员队伍，以完成可持续免疫研究中心的形成，该中心以优秀的基础科学调查为基础，采用转换方法，促进假设驱动的研究的双向工作台到床边应用，并具有区域性(如果不是全国性)影响。

DESCRIPTION (provided by applicant): Based on the success of the initial 10-year award, the ultimate goals of this COBRE renewal application are to complete the establishment at Dartmouth of a nationally recognized Center for Molecular, Cellular, and Translational Immunological Research, and to transition this COBRE Center for Immunological Research (COBRE-CIR) to an infrastructure-based, freestanding (from COBRE funding), sustainable center in five years. With the foundation of a long-standing Immunology Program, which has now been substantially enhanced by COBRE support, this proposal takes advantage of a highly interactive core of collaborative faculty at Dartmouth Medical School (DMS) and Dartmouth Hitchcock Medical Center (DHMC). With this expanded investigator base, a Phase III COBRE award will provide the resources to build the needed infrastructure to sustain the COBRE-CIR, further grow the Program, and facilitate inter-disciplinary basic science to translational immunological research. This infrastructure will include the continued mentored development of our immunological faculty, especially those investigators previously supported by COBRE; expansion of the COBRE Cores and their full integration with existing complementary cores and shared services at DMS/DHMC, particularly the Norris Cotton Cancer Center and the other Immunology and "Lung Biology" COBREs at Dartmouth and the University of Vermont; and an enhanced Pilot Project Program with targeting to mentored, collaborative, and/or translational/human systems research. Together with substantive Institutional commitment by DMS/DHMC, there is confidence that the strong existing cadre of investigators, already expanded and matured by the COBRE mechanism, can be further developed to complete the formation of a sustainable Center for Immunological Research that is grounded in excellent basic science investigation, embraces a translational approach to promote bidirectional bench-to-bedside application of hypothesis-driven research, and has a regional, if not also national, impact.