The Microbiome

说明; 该应用程序请求支持由Andrew T.作者声明：Dr.莱伊，将于2012年3月4日至9日在科罗拉多的基斯通举行。几个传统上不同的研究领域的新兴主题已经开始围绕这样一个概念进行整合，即居住在大多数人体外部表面的复杂微生物群落在健康和疾病中发挥着关键作用。具体而言，包括基本免疫系统发育、宿主-病原体相互作用、代谢疾病和癌症在内的过程都受到生活在我们体内的微生物群的组成和生物活性的极大影响。了解哺乳动物宿主如何调节其微生物群以及微生物群可以改变对各种疾病的易感性的无数方式是更好地了解许多疾病的关键机会，并随后提供促进人类健康的策略。因此，关于微生物组的Keystone研讨会会议的目标是促进对维持健康宿主-微生物群关系的机制的理解，并探索这种关系的扰动如何增加对各种疾病的易感性，特别是与慢性炎症相关的疾病。跨学科互动的机会将显着提高先天免疫力的并行会议：感知微生物和损伤信号，这将与本次会议分享一个主旨演讲和三个全体会议。 公共卫生相关性： 许多人类疾病-特别是与炎症相关的许多疾病-已被证明与居住在大多数外部人体表面的大量和多样化的微生物群体的改变有关。参加Keystone研讨会的与会者将更深入地了解粘膜免疫系统和微生物群相互影响的机制，以及它们正常关系的紊乱如何导致疾病。跨学科互动的机会将显着提高了先天免疫的并行会议：感知微生物和损伤信号，这将与本次会议分享一个主题演讲和三个全体会议。

DESCRIPTION; This application requests support for a Keystone Symposia meeting entitled The Microbiome, organized by Andrew T. Gewirtz, Fergus Shanahan and Ruth E. Ley, which will be held in Keystone, Colorado from March 4 - 9, 2012. Emerging themes from several traditionally disparate areas of research have begun to coalesce around the concept that the complex microbial communities that inhabit most external human surfaces play a key role in health and disease. Specifically, processes including basic immune system development, host- pathogen interactions, metabolic disease, and cancer are all greatly influenced by the composition and bioactivity of the microbiota that lives within us. Understanding how mammalian hosts regulate their microbiota and the myriad of ways by which the microbiota can alter susceptibility to a wide range of diseases is a key opportunity to better understand numerous diseases and, subsequently, provide strategies to promote human health. Thus, the goal of the Keystone Symposia meeting on The Microbiome is to facilitate the understanding of mechanisms that maintain a healthy host-microbiota relationship and explore how perturbations in this relationship increase susceptibility to a variety of diseases, especially those associated with chronic inflammation. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Innate Immunity: Sensing the Microbes and Damage Signals, which will share a keynote address and three plenary sessions with this meeting. PUBLIC HEALTH RELEVANCE: Numerous human diseases - especially the many diseases associated with inflammation - have been shown to be associated with alterations in the vast and diverse populations of microbes that populate most external human surfaces. Participants at the Keystone Symposia meeting on The Microbiome will gain a greater understanding of the mechanisms by which the mucosal immune system and microbiota influence each other and how disturbances in their normal relationships result in disease. Opportunities for interdisciplinary interactions will be significatly enhanced by the concurrent meeting on Innate Immunity: Sensing the Microbes and Damage Signals, which will share a keynote address and three plenary sessions with this meeting.