Mechanisms of Whole Organ Regeneration

描述（由申请人提供）：本提案要求支持由Alejandro Sanchez Alvarado组织的名为“全器官再生机制”的Keystone专题会议，该会议将于2012年4月1日至6日在科罗拉多州的Breckenridge举行。损伤后器官和器官系统的再生在动物中分布广泛但不均匀。为什么不是所有的动物都有器官再生，以及在那些能够再生的动物中，器官再生机制是否可能被保留，这些问题仍然悬而未决。近年来，使用更广泛的模式生物和使用遗传工具研究再生的能力不断提高，促使我们对动物再生生物学的理解取得了重大进展。本次会议旨在通过强调、比较和对比不同动物物种在再生能力和机制方面的异同，来描述再生的分子和细胞生物学基础。这些生物学发现将如何为再生医学、干细胞生物学和治疗学提供信息将被考虑和讨论。同时举行的再生组织工程与移植会议将大大增加跨学科互动的机会，该会议将分享一个开幕和闭幕主题演讲以及两个全体会议。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Mechanisms of Whole Organ Regeneration, organized by Alejandro Sanchez Alvarado, which will be held in Breckenridge, Colorado from April 1 - 6, 2012. The regeneration of organs and organ systems after injury is widely, but unevenly, distributed among animals. Why organ regeneration is not shared by all animals, and whether mechanisms may or may not be conserved among those animals that can regenerate remain open questions. In recent years, the use of a wider range of model organisms and an increasing ability to use genetic tools to study regeneration has spurred significant progress in our understanding of animal regenerative biology. This meeting aims to delineate the molecular and cell biological basis of regeneration by highlighting, comparing and contrasting the differences and similarities in regenerative capabilities and mechanisms among diverse animal species. How these biological findings may inform regenerative medicine and stem-cell biology and therapeutics will be considered and discussed. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Regenerative Tissue Engineering and Transplantation, which will share an opening and closing keynote address as well as two plenary sessions with this meeting.