Neurodegenerative Diseases: New Insights and Therapeutic Opportunities

摘要 要求为题为“神经退行性疾病：新的见解”的Keystone专题讨论会提供支助 和治疗机会，由博士组织。Dawson，Joseph W. Lewcock和Fred H.盖奇 会议将于2019年6月16日至20日在科罗拉多的Keystone举行。 神经退行性疾病的全球负担是惊人的，并以惊人的速度增长， 人口老龄化。虽然阿尔茨海默氏病和相关的痴呆症，以及帕金森氏病和 相关的疾病，占大多数的人受苦，也有不太常见，但同样 毁灭性的疾病技术和概念的进步正在揭示疾病的机制， 新的治疗机会。错误折叠的蛋白质被认为是 神经退行性疾病，但最近有一种认识，这些错误折叠的蛋白质可能作为 种子的模板正常蛋白质的错误折叠，这些种子的传播可能会导致疾病 进展，并且可能存在具有不同毒性的这些种子的不同菌株。生物物理 对这些蛋白质的分析揭示了这些内在的相变和液体分层的作用 无序蛋白质突触丢失是神经退行性变的一个重要特征， 神经元损失，但在疾病表现和功能丧失中至关重要。神经胶质和免疫 激活导致神经变性和突触丢失，如果神经变性和突触丢失， 疾病的进程是要缓和或停止。本次会议旨在解决当前的知识状态 在这些新兴领域，并提供这些主题的高级讨论;互动的机会 来自不同研究领域的科学家之间的合作将促进新的合作， 治疗机会，以应对即将到来的危机，并为那些患有 神经退行性疾病

ABSTRACT Support is requested for a Keystone Symposia conference entitled Neurodegenerative Diseases: New Insights and Therapeutic Opportunities, organized by Drs. Valina L. Dawson, Joseph W. Lewcock and Fred H. Gage. The conference will be held in Keystone, Colorado from June 16-20, 2019. The global burden of neurodegenerative disease is staggering and growing at an alarming rate as the population ages. While Alzheimer's disease and related dementias, as well as, Parkinson's disease and related disorders, account for the majority of those afflicted, there are also less common but equally devastating diseases. Technical and conceptual advances are revealing disease mechanisms and providing new therapeutic opportunities. Misfolded proteins have been understood to be at the center of neurodegenerative diseases but recently there is an appreciation that these misfolded proteins may serve as seeds to template the misfolding of normal proteins, that transmission of these seeds may underlie disease progression, and that there may be different strains of these seeds with differential toxicities. Biophysical analysis of these proteins reveals a role for phase transition and liquid demixing of these intrinsically disordered proteins. Synaptic loss is an important feature of neurodegeneration which may occur long before neuronal loss, but be critically important in disease presentation and loss of function. Glia and immune activation contribute to neurodegeneration and synaptic loss, and must be understood and controlled if the disease process is to be tempered or stopped. This conference aims to address the current state of knowledge in these emerging area and to provide advanced discussion of these topics; the opportunity for interaction between scientists from different fields of research will foster new collaborations that may lead to new therapeutic opportunities to combat the coming crisis and provide medical care for those suffering from neurodegenerative diseases.