Keystone Symposia Annual Meeting Series on Obesity

描述(由申请者提供)：申请资助一系列以肥胖为主题的年度Keystone研讨会。该系列的第一次会议将于2015年举行，题为肥胖与代谢综合征：线粒体与能量消耗，由Johan Auwerx、Eleftheria Maratos-Flier和Thomas Langer组织。会议将于2015年3月22日至27日在加拿大不列颠哥伦比亚省惠斯勒举行。21世纪的一个医学挑战是预期寿命史无前例的增加，同时慢性多因素疾病的发病率和流行率大幅增加。典型的疾病例子包括代谢障碍，如肥胖和2型糖尿病，这些疾病往往与非酒精性肝病以及冠状动脉、外周和中央血管疾病等并存疾病有关。总而言之，这一系列疾病通常被称为代谢综合征。在过去的十年里，很明显，细胞代谢的变化往往与线粒体的数量、形态和功能的变化有关，这些细胞变化是系统性代谢异常的基础，这些代谢异常是代谢综合征的许多临床特征的特征。Keystone研讨会2015年关于肥胖和代谢综合征的会议将讨论新的发现，将肝脏、肌肉和肠道等周围组织的线粒体功能与代谢综合征的系统性异常联系起来。我们将回顾发现基于改变线粒体功能的新疗法的可能性。由于线粒体功能现在被认为除了在细胞水平上控制能量平衡外，还可以在生物水平上控制代谢平衡，这次会议将创造一个真正的跨学科环境，将生物能量学领域的基础科学家聚集在一起， 对代谢性疾病感兴趣的线粒体和细胞生物学、生理学和临床医生， 在这一领域培育创新思想。同时召开的肝脏代谢和非酒精性脂肪性肝病会议将显著增加跨学科互动的机会，该会议将与本次会议共享一次全体会议。

DESCRIPTION (provided by applicant): Support is requested for a series of annual Keystone Symposia meetings on the topic of Obesity. The first meeting in the series will be held in 2015 and is entitled Obesity and the Metabolic Syndrome: Mitochondria and Energy Expenditure, and is being organized by Johan Auwerx, Eleftheria Maratos-Flier and Thomas Langer. The meeting will be held in Whistler, British Columbia, Canada from March 22-27, 2015. A medical challenge of the 21st century is the coupling of an unprecedented increase in life expectancy with a large increase in incidence and prevalence of chronic multifactorial diseases. Classic disease examples include disorders of metabolism such as obesity and type 2 diabetes mellitus, which are often associated with co- morbidities including non-alcoholic liver disease and coronary, peripheral and central vascular disease. Collectively the spectrum of disorders is often referred to as the metabolic syndrome. Over the past decade, it has become evident that shifts in cellular metabolism are often linked to changes in the number, morphology, and function of mitochondria, and that these cellular changes underlie systemic metabolic abnormalities that characterize the many clinical features of the metabolic syndrome. Keystone Symposia's 2015 meeting on Obesity and the Metabolic Syndrome will discuss novel findings that link mitochondrial function in peripheral tissues, such as liver, muscle and gut, with the systemic abnormalities of the metabolic syndrome. The potential for identifying new therapeutics that are based on modifying mitochondrial function will be reviewed. As mitochondrial function is now acknowledged to also control metabolic homeostasis on an organismal level in addition to controlling energy homeostasis at the cellular level this meeting will create a truly interdisciplinary environment that brings together basic scientists in the fields of bioenergetics, mitochondrial and cell biology, physiology and clinicians with an interest in metabolic disease, to foster innovative ideas in this area. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Liver Metabolism and Nonalcoholic Fatty Liver Disease, which will share a plenary session with this meeting.