Novel Approaches Against Emerging Antimicrobial Resistance

摘要 请求为题为《反对新兴的新方法》的Keystone研讨会提供支助 抗菌素耐药性，由陈文华博士和Deborah T.Hung博士组织。会议将举行 将于2022年2月13日至16日在加拿大艾伯塔省班夫举行。 传染病显然是对人类健康和全球健康的最大威胁之一。 稳定性。这些威胁中最主要的是抗生素耐药性的增加，这危及我们的治疗能力 其他可以治愈的感染。发现和开发新的代理以填补现有渠道的能力 抗生素的流失是因为耐药性的增加到目前为止一直是有限的。本次Keystone研讨会的目标是 会议将介绍抗生素发现的尖端方法，包括扩展的应用 化学空间、系统化学生物学、人工智能和治疗耐药性的新策略 感染，包括CRISPR、疫苗、抗体、噬菌体和结合物。承诺、挑战和 将在总结经验教训的背景下讨论这些新办法和战略的发展道路 来自以前的抗生素开发计划，以及临床和监管途径的新创新。 此外，本次会议还将与《人类微生物组：生态与进化》联合举行。这 配对将有助于探索抗生素对微生物组的影响以及微生物组对 抗生素耐药性。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Novel Approaches Against Emerging Antimicrobial Resistance, organized by Drs. Man-Wah Tan and Deborah T. Hung. The conference will be held in Banff, Alberta, Canada from February 13-16, 2022. It has become clear that infectious diseases are among the greatest threats to human health and global stability. Chief among these threats is the rise in antibiotic resistance, which endangers our ability to treat otherwise curable infections. The capacity to discover and develop novel agents to fill the pipeline as existing antibiotics are lost to increasing resistance has to date been limited. The goal of this Keystone Symposia conference is to present cutting-edge approaches to antibiotic discovery, including application of expanded chemical space, systems chemical biology, and artificial intelligence and novel strategies for treating resistant infection, including CRISPR, vaccines, antibodies, phages and conjugates. The promise, challenges, and development paths of these new approaches and strategies will be discussed in the context of lessons learned from prior antibiotic development programs, and new innovations in clinical and regulatory pathways. Additionally, this conference will be held jointly with “The Human Microbiome: Ecology and Evolution.” This pairing will help to facilitate exploration of the impact of antibiotics on the microbiome and the microbiome on antibiotic resistance.