Precision Engineering of the Genome, Epigenome, and Transcriptome

摘要 请求支持题为《基因组的精密工程》的Keystone研讨会， 首页--期刊主要分类--期刊细介绍--期刊题录与文摘--期刊详细文摘内容 乌尔诺夫。这次会议将是Keystone Symposa的eSymposa会议系列的一部分，这些会议是虚拟的 事件。本次在线会议的日期为2021年3月7日至11日。 在过去的几年里，新的基因组工程工具已经彻底改变了审问 生物系统，设计创新的生物技术，以及模拟和治疗人类疾病。基因组 工程领域继续以疯狂的步伐发展，包括新基础的发展 工具及其在满足社会需求方面的应用。本次Keystone研讨会将讨论这一问题 一系列进展，包括基因组、表观基因组和 转录组精密工程。会议还将重点介绍人类发展的最新进展。 使用这些工具的治疗，包括新的临床试验结果和新模式的临床前范例 干预的结果。会议将包括广泛的研究界感兴趣的各种主题， 包括下一代应用，如高通量筛选、合成生物学和染色质 以及核糖核酸成像和诊断。最后，会议最后将列举一些例子，说明新兴的 可以集成各种技术，以实现前所未有的细胞过程分辨率，例如基因组 工程学与单细胞分析方法相结合。总体而言，本次会议将在其历史的基础上 通过让受众熟悉工具开发的最新进展取得成功，提供了关于 这些工具的临床应用，并对受影响的科学领域的广度产生赞赏 基因组工程革命。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Precision Engineering of the Genome, Epigenome and Transcriptome, organized by Drs. Charles Gersbach, Rachel E. Haurwitz and Fyodor D. Urnov. The conference will be part of Keystone Symposia’s eSymposia Conference Series, which are virtual events. The dates for this online conference will be March 7-11, 2021. Over the last several years, new genome engineering tools have revolutionized the ability to interrogate biological systems, engineer innovative biotechnologies, and model and treat human disease. The genome engineering field continues to evolve at a frenzied pace, including both the development of new fundamental tools and their application to addressing societal needs. This Keystone Symposia conference will cover this spectrum of advances, including the most recent technological innovations in genome, epigenome, and transcriptome precision engineering. The conference will also highlight recent advances in developing human therapeutics with these tools, including emerging clinical trial results and preclinical examples of novel modes of intervention. The conference will include a variety of topics of interest to the broad research community, including next-generation applications such as high-throughput screening, synthetic biology, and chromatin and RNA imaging and diagnostics. Finally, the conference will conclude with examples of how emerging technologies can be integrated for an unprecedented level of resolution of cellular processes, such as genome engineering combined with single-cell analysis methods. Collectively, this meeting will build on its history of success by familiarizing the audience with the latest advances in tool development, providing an update on clinical application of these tools, and generating an appreciation for the breadth of scientific areas impacted by the Genome Engineering Revolution.