Genomic Instability and DNA Repair

摘要 请求为题为“基因组不稳定性和DNA修复”的Keystone专题讨论会提供支助， 由Katharina Schlacher、Irene Chiolo和Ralph Scully博士组织。会议将在惠斯勒举行， BC，加拿大，2023年3月19日至23日。 DNA复制和修复是启动，协调和影响广泛的生物学行为的关键过程。 基本的生理反应，最终促进细胞分裂，基因组稳定性和适当的细胞 physiology.基因组稳定性领域有着丰富的直接导致发展的机制性理解 小分子抑制剂，如PARP抑制剂，现在在临床上作为抗癌药物使用 剂.然而，核基因组稳定性的参与者并不是在真空中行动，而是相互作用、沟通和交流。 与各种内在和外在的细胞过程合作。这个领域正处于下一个阶段的尖端， 了解不同的细胞和生理反应如何直接与基因组稳定性一起工作 分子水平上的机制以及如何利用这种理解来开发新的治疗策略 对抗人类疾病炎症和免疫信号反应的控制和治理， 特别是与复制和染色质反应有关的蛋白质是一个潜在的强有力的前沿联系， 鉴于这些反应在癌症免疫治疗期间的重要性，这是由以下具体实现的： 单分子靶向剂的持续发展，其产生于强分子生物学， 对这个领域的理解。如何控制和指导炎症信号的知识将推动我们的研究。 了解如何控制癌症以外的疾病这包括病毒感染，特别是 在最近的大流行期间与公共卫生相关。本次Keystone研讨会将重点介绍 最新的进展和新兴的概念，在该领域，渴望促进丰富的讨论，特别是集中在 对医学生物学、疾病和治疗策略的影响。本次会议聚焦DNA 复制和修复将与精密基因组工程会议联合举行， 这两个互补领域之间的交流机会。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Genomic Instability and DNA Repair, organized by Drs. Katharina Schlacher, Irene Chiolo and Ralph Scully. The conference will be held in Whistler, BC, Canada from March 19-23, 2023. DNA replication and repair are critical processes that initiate, orchestrate, and affect a broad range of fundamental physiological reactions, ultimately promoting cell division, genome stability, and proper cellular physiology. The field of genome stability is rich in mechanistic understanding that directly led to development of small molecule inhibitors such as PARP inhibitors, now used standardly in the clinic as anti-cancer agents. Nuclear genome stability actors, however, do not act in a vacuum, but interact, communicate and collaborate with diverse intrinsic and extrinsic cellular processes. The field is at the cusp of the next level of understanding of how diverse cellular and physiological reactions directly work together with genome stability mechanisms on a molecular level and how to use this understanding to develop new treatment strategies against human diseases. The control and governance of inflammatory and immune signaling reactions as it relates to replication and chromatin reactions in particular is a potentially potent cutting-edge connection for the field, given the importance of these reactions during immunotherapy of cancer. This is enabled specifically by the continued development of single molecule targeting agents, which have arise from the strong molecular understanding of the field. The knowledge of how to control and direct inflammatory signaling will propel our understanding of how to control diseases beyond cancer. This includes viral infections, which are of particular relevance to public health during the recent pandemic. This Keystone Symposia conference will highlight the latest advances and emerging concepts in the field, aspiring to prompt rich discussions especially focused on implications for medical biology, disease and treatment strategies. This conference focusing on DNA replication and repair will be held jointly with a conference on Precision Genome Engineering, providing outstanding opportunities for cross-fertilization between these two complementary fields.