Long COVID and Post Acute Sequalae of SARS CoV 2 (PASC): Pathogenesis and Treatment

摘要 请求支持一个题为长期COVID和急性后后遗症的Keystone研讨会会议， SARS-CoV-2（PASC）：发病机制和治疗，由Michael Holtzman，Steven Deeks，Resia博士组织 Pretorius和Catherine Blish。会议将于2023年8月27日至30日在新墨西哥州圣达菲举行。 包括SARS-CoV-2在内的许多感染都会引起急性疾病，最终会消退，无论是否对患者造成伤害。 宿主组织然而，在一些人中，急性感染引发了一种全身性、持续性的慢性疾病， 几个月后，又有几个月。此外，康复者的比例 从急性感染，但随后开始发展为慢性症状（又名，长期COVID），或其他一些主要 并发症，如心脏病、中风或糖尿病（统称为急性后 SARS-CoV-2或PASC的后遗症）约占该人群的50%，这取决于PASC的定义。 因此，本次Keystone研讨会旨在了解从急性疾病到慢性疾病的进展， 疾病，以及解决长期COVID和PASC，第一次，与机制为基础的治疗 战略布局会议的目的是多学科的性质，将有代表从 独特的科学，技术和临床观点，地理，学术和商业 部门多样性。预计这一广泛的观点将有助于促进互动， 解决前所未有的医疗保健问题。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Long COVID and Post-Acute Sequelae of SARS-CoV-2 (PASC): Pathogenesis and Treatment, organized by Drs. Michael Holtzman, Steven Deeks, Resia Pretorius and Catherine Blish. The conference will be held in Santa Fe, New Mexico, August 27-30, 2023. Many infections, including SARS-CoV-2, cause an acute illness that eventually resolves, with or without injury to host tissues. However, in some people, the acute infection triggers a chronic disease that is systemic, persistent (months to years) and, for some, profoundly disabling. Moreover, the proportion of those who have recovered from acute infection but then begin to develop chronic symptoms (aka, Long COVID), or some other major complication such heart disease, stroke, or diabetes mellitus (collectively referred to as the Post-Acute Sequelae of SARS-CoV-2, or PASC) is about 50% of this population, depending on how PASC is defined. Therefore, this Keystone Symposia conference aims to understand the progression from acute illness to chronic disease as well as address Long COVID and PASC, for the first time, with mechanism-based therapeutic strategies. The conference is designed to be multidisciplinary in nature and will have representation from distinct scientific, technological, and clinical perspectives with geographical, academic, and commercial sector diversity. It is anticipated that this broad set of perspectives will help to foster interactions leading to synergistic solutions to an unprecedented health care problem.