Immunity and Aging

摘要 请求支持由博士组织的题为免疫和衰老的Keystone研讨会。 丹妮卡·陈、孙旭和琼·曼尼克。会议将于10月1日至4日在加拿大惠斯勒举行， 2023年。 老龄化是导致各种慢性病和死亡的最大单一风险因素。一位杰出的 人类生物学中的问题是，我们如何失去维持动态平衡的能力，并变得容易患上 疾病和死亡率。然而，随着过去十年突破性研究的出现，有 有证据表明，衰老器官系统的功能下降是由一定数量的生物学上的 机械装置。例如，最近的单细胞测序研究表明，一种机制有助于 衰老免疫系统的功能障碍是免疫细胞在整个组织中广泛的基础激活。 此外，老化的免疫系统功能障碍导致对疫苗和 老年人中的传染病，正如最近新冠肺炎大流行所强调的那样。这个基石 研讨会将为研究人员提供一个国际场所，讨论这些及时的主题， 具体地说，为了了解免疫系统在衰老过程中如何变得失调，以及如何 衰老的免疫系统影响着组织的功能、机体的健康寿命和生存。本节目 涉及的问题包括：(I)造血干细胞的老化如何导致衰老功能障碍 免疫系统和对远处组织的影响以及(Ii)先天免疫和获得性免疫如何与年龄相关的变化 功能损害免疫力。其他会议将讨论衰老相关炎症的起源和 炎症如何影响组织功能并导致与衰老相关的疾病。这次会议将给我们带来 来自多个领域的研究人员聚集在一起-免疫学、衰老、新陈代谢、干细胞生物学和 神经生物学--推进免疫和衰老的前沿。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Immunity and Aging, organized by Drs. Danica Chen, Sun Hur and Joan Mannick. The conference will be held in Whistler, Canada from October 1-4, 2023. Aging is the single largest risk factor for a wide spectrum of chronic diseases and mortality. An outstanding question in human biology is how we lose the ability to maintain homeostasis and become susceptible to diseases and mortality. However, as groundbreaking research has emerged over the past decade, there is evidence that the decline in function of aging organ systems is caused by a discreet number of biological mechanisms. For instance, recent single cell sequencing studies suggest that one mechanism contributing to dysfunction of the aging immune system is a widespread basal activation of immune cells across tissues. Additionally, dysfunction of the aging immune system results in suboptimal immune responses to vaccines and infectious diseases in older adults, as has been highlighted recently by the COVID-19 pandemic. This Keystone Symposia conference will provide an international venue for researchers to discuss these timely topics, specifically, to understand how the immune system becomes dysregulated during the aging process and how the aging immune system impinges upon the tissue functions, organismal health span and survival. This program touches on questions including: (i) how aging of hematopoietic stem cells contribute to dysfunction of the aging immune system and impacts distant tissues and (ii) how age-related changes in innate and adaptive immune function compromise immunity. Other sessions will discuss the origins of aging-associated inflammation and how inflammation impacts tissue functions and contributes to aging-related conditions. The conference will bring together investigators from multiple fields—immunology, aging, metabolism, stem cell biology and neurobiology—to advance the frontier of immunity and aging.