Circulating Metabolic Intermediates as Fuels and Signals

摘要 请求支助题为《作为燃料的代谢中间体循环》的Keystone专题讨论会 和Signals，由Sven Enerbäck博士、Joshua Rabinowitz博士和Sarah-Maria Fendt组织。会议将于 将于2023年10月8日至11日在犹他州雪鸟举行。 代谢性疾病，如中风、心脏病、糖尿病、癌症、肥胖症和NASH，仍然是 死亡和残疾。其中一个原因是对新陈代谢及其调节的了解不完全。 新的数据表明，通常被视为废物或良性中间体的代谢物实际上非常 重要的燃料和信号。例如，乳酸已成为一种重要的能量底物和琥珀酸 作为肌肉重塑的驱动力，反映了循环代谢中间体许多未被研究的角色。 与葡萄糖、氨基酸和脂肪等经典的“燃料”相比，这类中间体的重要性开始显现。 关于新陈代谢如何控制的新视角。因此，这一领域将迎来进一步的突破，无论是在 了解新的生物学，并为干预提供新的靶点。本次Keystone研讨会 将汇集该领域的顶尖专家，回顾最新研究并讨论该领域的挑战 正面临着。最后，本次会议是与机制问题基石专题讨论会联合举行的。 微生物群--免疫相互作用--的未来十年。预计这次剥离将带来新的 科学协作和新技术方法的实施，旨在了解 微生物区系、免疫和代谢相互作用的潜在机制。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Circulating Metabolic Intermediates as Fuels and Signals, organized by Drs. Sven Enerbäck, Joshua Rabinowitz and Sarah-Maria Fendt. The conference will be held in Snowbird, Utah from October 8-11, 2023. Metabolic diseases such as stroke, heart disease, diabetes, cancer, obesity, and NASH remain major causes of death and disability. One reason for this is due to the incomplete understanding of metabolism and its regulation. New data indicate that metabolites normally viewed as wastes or benign intermediates are actually very important fuels and signals. For example, lactate has emerged as an important energy substrate and succinate as a driver of muscle remodeling, reflecting the many underexplored roles of circulating metabolic intermediates. The importance of such intermediates, as opposed to classical “fuels” like glucose, amino acids and fat, opens a new perspective on how metabolism is controlled. Thus, this field is primed for further breakthroughs, both in understanding of new biology and in offering new targets for intervention. This Keystone Symposia conference will bring together the leading experts in the field to review the latest research and discuss challenges the field is facing. Finally, this conference is being held jointly with the Keystone Symposia conference on Mechanisms of Microbiota-Immune Interactions-Towards the Next Decade. It is anticipated that this paring will lead to new scientific collaborations and the implementation of new technological approaches directed at understanding the underlying mechanisms of microbiota-immune and -metabolic interactions.