Autophagy

描述（由申请人提供）：本提案请求支持由Ana Maria Cuervo、大卫C. Rubinsztein和托马斯P. Neufeld，将于2011年3月27日至4月1日在加拿大不列颠哥伦比亚省惠斯勒举行。自噬是一种基本的细胞过程，涉及广泛的细胞事件，包括发育，衰老，免疫和细胞死亡。近年来，该领域经历了令人眩晕的扩张，这在很大程度上是由于自噬功能障碍与癌症、代谢紊乱、不同类型的免疫紊乱、肌肉疾病和神经变性有关。Keystone Symposia自噬会议的目标是促进目前对这一过程感兴趣的不同研究领域之间的交流，并促进一种综合方法来定义自噬在生理和病理过程中的作用。本次会议的第一部分侧重于一系列会议，国际专家将介绍有关不同生物体中不同自噬途径的机制和调控的前沿成果。第二系列会议的重点是越来越多的自噬功能障碍和人类疾病之间的联系。该计划还包括围绕四个主题组织的研讨会：跟踪自噬的技术，实验系统，临床相关性和大筛选分析。这些讲习班将作为一个平台，积极讨论与实地高度相关的议题，并将提供一个渠道，提高对需要今后关注的领域的认识。本着Keystone研讨会形式的精神，本次会议的指导原则将是介绍新的，未发表的工作和自由不受阻碍的讨论结果。 公共卫生相关性：自噬是一种基本的细胞过程，涉及广泛的细胞事件，包括发育，衰老，免疫和细胞死亡。自噬的Keystone研讨会会议将作为讨论与自噬过程相关的快速发展的发现的基础，包括但不限于，参与其执行和调节的分子机制，细胞和生物体水平的关键生理功能，以及自噬功能障碍与人类疾病之间越来越多的联系。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Autophagy, organized by Ana Maria Cuervo, David C. Rubinsztein and Thomas P. Neufeld, which will be held in Whistler, British Columbia, Canada from March 27 - April 1, 2011. Autophagy is a basic cellular process involved in a wide array of cellular events including development, aging, immunity and cell death. This field has undergone a vertiginous expansion in recent years due, for the most part, to the fact that autophagic dysfunction has been associated with cancer, metabolic disorders, different types of immune disorders, muscular diseases and neurodegeneration. The goal of the Keystone Symposia meeting on Autophagy is to facilitate communication among the different fields of research that are currently interested in this process and to foment an integrated approach to defining the role of autophagy in physiological and pathological processes. The first part of this meeting focuses on a series of sessions in which international experts will present cutting-edge results regarding mechanisms and regulation of the different autophagic pathways in different organisms. A second series of sessions focuses on the growing number of connections between autophagic dysfunction and human disorders. The program also includes workshops organized around four topics: techniques to track autophagy, experimental systems, clinical relevance, and large-screening analysis. These workshops will serve as a platform for dynamic discussion of topics of high relevance for the field and will provide an avenue to bring awareness on the areas that need future attention. In the spirit of the Keystone Symposia format, the guiding principles of this meeting will be presentation of new, unpublished work and free unhampered discussion of the results. PUBLIC HEALTH RELEVANCE: Autophagy is a basic cellular process involved in a wide array of cellular events including development, aging, immunity and cell death. The Keystone Symposia meeting on Autophagy will serve as basis for discussion of the rapidly advancing discoveries related to the autophagic process including, but not limited to, the molecular mechanisms involved in its execution and regulation, the key physiological functions both at the cellular and organismal level, and the growing number of connections between malfunctions in autophagy and human disease.