Therapeutic strategy of neurodegenerative disease using microRNA

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We identified RNA-binding proteins that influence most strongly on the stability of the mRNA of Neuropathology spinocerebellar degeneration and (HD) Huntington's disease (SCD) in cultured cell experiments. In cell culture experiments, I found that CUGBP is an RNA-binding protein, Elav-like family (CELF) suppresses the mRNA expression of pathogenesis of SCD gene and HD. In addition, this expression suppression effect was not independent of the length of the array length of the gene-specific pathogenesis of SCD and HD in (CAG repeat number). Currently, it is administered to a mouse model of SCD and HD prepared and elucidation of the mechanism by which CELF proteins affect the expression of mRNA of pathogenesis gene of SCD and HD, the AAV expressing the CELF proteins, we examined the therapeutic effect.