Protein-RNA Interactions

蛋白质-RNA相互作用

• 批准号: 10540278
• 负责人: TERRY L. SHEPPARD
• 金额: $ 0.35万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10540278
• 关键词: Address; Area; Binding Proteins; Biological Sciences; Biology; Canada; Categories; Cellular biology; Collaborations; Communities; DNA; Development; Disease; Drug Targeting; Educational workshop; Gene Expression; Gene Expression Regulation; Genes; Genetic Diseases; Genetic Variation; Human; Knowledge; Measures; Mentors; Methodology; Methods; Microscopy; Modality; Outcome; Participant; Phase; Physical condensation; Play; Proteins; RNA; Research; Research Personnel; Role; Science; Scientist; Technology; Therapeutic; Therapeutic Intervention; Training; Work; career; clinical practice; expectation; insight; learning network; multidisciplinary; next generation; novel; posters; programs; single cell technology; symposium; therapy outcome

ABSTRACT Support is requested for a Keystone Symposia conference entitled Protein-RNA Interactions, organized by Drs. Gene Yeo, Wendy Gilbert and Lori Passmore. The conference will be held in Vancouver, Canada from January 29- February 1, 2023. Ribonucleic acid (RNA) binding proteins (RBPs) are a major category of regulators encoded by more than two thousand human genes. Over the last few years, millions of protein-RNA interactions in a myriad of cellular contexts have been measured by increasingly scalable technologies, providing opportunity for deeper connections with genetics and disease. In parallel, stunning breakthroughs in microscopy and structural methods have revealed fundamental insights into protein-RNA interactions. This conference addresses growing excitement from both the basic and translational life sciences community in imagining protein-RNA interactions as a treasure trove of new biology and drug targets. This conference is unique in that it will provide a forum to assemble multi-disciplinary leaders in various themes in the RNA community to cross- fertilize emerging ideas in fundamental protein-RNA science. Other sessions will introduce a diversity of newcomers to the newest methods and results in the field and introduce and identify new targets and modalities for therapeutic opportunities. Finally, this conference will be held jointly with the Keystone Symposia conference on Biomolecular Condensates which is a natural collaboration as RNA binding proteins play major roles in condensation of protein-RNA/DNA interactions. Participants at both conferences will be able to network and develop new collaborations through shared sessions and meals.

摘要 要求支持一个基石研讨会会议题为蛋白质-RNA相互作用，由博士组织。 吉恩·杨，温迪·吉尔伯特和洛里·帕斯莫尔。会议将于2009年10月25日至26日在加拿大温哥华举行。 2023年1月29日至2月1日。 核糖核酸（RNA）结合蛋白（RBP）是由两个以上的基因编码的主要调节因子。 一千个人类基因在过去的几年里，在无数的细胞中， 环境已经通过日益可扩展的技术来衡量， 与遗传和疾病的联系。与此同时，显微镜和结构 方法揭示了蛋白质-RNA相互作用的基本见解。本次会议讨论 基础和转化生命科学界对蛋白质-RNA的想象越来越兴奋， 相互作用是新生物学和药物靶点的宝库。本次会议的独特之处在于，它将 提供一个论坛，聚集RNA社区中各种主题的多学科领导者， 丰富了基础蛋白质-RNA科学的新思想。其他会议将介绍多样性， 新来的人在该领域的最新方法和结果，并介绍和确定新的目标， 治疗机会的模式。最后，本次发布会将与Keystone联合举办 生物分子缩合物研讨会，这是一个自然的合作，作为RNA结合蛋白 在蛋白质-RNA/DNA相互作用的缩合中起主要作用。两次会议的与会者将 能够通过共享会议和膳食建立网络并发展新的合作。