Protein-RNA Interactions

摘要 请求支持一个题为蛋白质-RNA相互作用的Keystone研讨会。 吉恩·杨、温迪·吉尔伯特和洛里·帕斯莫尔。会议将于以下时间在加拿大温哥华举行： 2023年1月29日-2月1日。 核糖核酸(Rna)结合蛋白(Rbp)是一类主要的调节子，由两个以上的 上千个人类基因。在过去的几年里，无数细胞中数百万的蛋白质-RNA相互作用 环境已经通过可扩展性越来越强的技术来衡量，为更深层次的 与遗传学和疾病的联系。同时，在显微镜和结构方面的惊人突破 方法揭示了对蛋白质-RNA相互作用的基本见解。这次会议的主题是 基础生命科学界和翻译生命科学界对想象蛋白质-RNA的兴趣日益高涨 相互作用是新的生物学和药物靶点的宝库。这次会议的独特之处在于它将 提供一个论坛，将RNA社区中不同主题的多学科领导者聚集在一起，以跨 在基础蛋白质-RNA科学中孕育新兴的想法。其他会议将介绍各种 新来者了解该领域的最新方法和结果，并引入和确定新的目标和 治疗机会的方式。最后，本次会议将与Keystone联合举行 生物分子凝聚物作为RNA结合蛋白的自然协作 在蛋白质-RNA/DNA相互作用的缩合中起主要作用。两个会议的参与者都将是 能够通过共享会议和用餐来建立网络并发展新的协作。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Protein-RNA Interactions, organized by Drs. Gene Yeo, Wendy Gilbert and Lori Passmore. The conference will be held in Vancouver, Canada from January 29- February 1, 2023. Ribonucleic acid (RNA) binding proteins (RBPs) are a major category of regulators encoded by more than two thousand human genes. Over the last few years, millions of protein-RNA interactions in a myriad of cellular contexts have been measured by increasingly scalable technologies, providing opportunity for deeper connections with genetics and disease. In parallel, stunning breakthroughs in microscopy and structural methods have revealed fundamental insights into protein-RNA interactions. This conference addresses growing excitement from both the basic and translational life sciences community in imagining protein-RNA interactions as a treasure trove of new biology and drug targets. This conference is unique in that it will provide a forum to assemble multi-disciplinary leaders in various themes in the RNA community to cross- fertilize emerging ideas in fundamental protein-RNA science. Other sessions will introduce a diversity of newcomers to the newest methods and results in the field and introduce and identify new targets and modalities for therapeutic opportunities. Finally, this conference will be held jointly with the Keystone Symposia conference on Biomolecular Condensates which is a natural collaboration as RNA binding proteins play major roles in condensation of protein-RNA/DNA interactions. Participants at both conferences will be able to network and develop new collaborations through shared sessions and meals.