Engineering Multi-Cellular Living Systems

摘要 请求为题为工程多细胞生命系统的Keystone研讨会提供支持 组织者：罗杰·D·卡姆博士、努里亚·蒙特塞拉特·普利多、傅建平。会议将在#年举行 科罗拉多州Keystone，2022年4月3日至6日。 发展设计、设计和生产复杂的多细胞工程生命系统的能力 (M-CELS)模拟自然过程(发育、再生和疾病)或创造新的 功能性是科学界面临的重大挑战。这些产品的制造和设计 复杂的多细胞机器和系统(例如，芯片上器官模型、生物机器人和有机体) 需要对细胞与环境之间的相互作用有基本的了解，它们通过 生物化学和机械线索，以及通过计算的功能细胞团的协调行为 和实验方法。细胞相互作用，跨尺度控制(从亚细胞结构到多细胞结构) 蜂窝系统)和行为将是会议的中心主题。这次会议的主要目的是 是召集一个多学科的前瞻性研究小组，寻求探索这些复杂的 生物相互作用及其产生的紧急行为，目标是负责任地创造 具有特定功能的工程多细胞系统。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Engineering Multi-Cellular Living Systems organized by Drs. Roger D. Kamm, Nuria Montserrat Pulido, Jianping Fu. The conference will be held in Keystone, Colorado from April 3-6, 2022. Developing the capability to design, engineer and produce complex, multi-cellular engineered living systems (M-CELS) to emulate natural processes (development, regeneration, and disease) or to create new functionality is a grand challenge facing the scientific community. The manufacturing and design of these complex multicellular machines and systems (e.g., organ-on-chip models, biological robots, and organoids) require fundamental understanding of interactions between cells and their environment, their control by biochemical and mechanical cues, and coordinated behavior of functional cell clusters through computational and experimental methods. Cell interactions, controls across scales (from subcellular structures to multi- cellular systems) and behaviors will be central themes of the conference. The primary aim of this conference is to bring together a multidisciplinary group of forward-looking researchers seeking to explore these complex biological interactions and the emergent behaviors they produce, with the goal of creating responsibly engineered multi-cellular systems with specific functions.