Small Regulatory RNAs: From Bench to Bedside

摘要 请求支持一次题为《小调控RNA：从板凳到板凳》的Keystone研讨会 床边，由弗兰克·斯拉克博士、约尔格·沃格尔博士、伊万·马丁内斯博士和卡琳·施密特博士组织。会议将于 2022年5月1日至4日在新墨西哥州圣达菲举行。 基于RNA的疗法已经被批准用于各种人类疾病。一套庞大而多样的 小的调节RNA已经成为发育和细胞中基因表达的关键调节因子 动态平衡，常在人类疾病中错误表达。它们的小尺寸和分子性质 使小RNA成为靶标和治疗药物，并为医生提供强大的新电池 诊断和治疗疾病的试剂。然而，尽管已知数千个小RNA，但相对较少 已知它们的作用和靶点，但这些分子在临床上的应用仍然有限。这 会议计划旨在探索令人兴奋的小调控RNA的生物学，并强调 对小RNA在基本过程中所起作用的最新研究。此外，其他 会议将集中讨论利用这些RNAs的力量作为抗击 并提供将推动发明强大的临床工具的基本理解。专属的 会议将集中讨论microRNA和siRNA在人们高度感兴趣的领域的治疗应用，如 肿瘤学，以及从罕见的遗传疾病到肾脏疾病、纤维化、肝炎的各种情况 和伤口愈合。预计这次会议将吸引许多在小型研究机构工作的研究人员 RNAs将走到一起，参与关键的讨论，这将推动该领域的发展，并加速替补席 这项技术的床边翻译。最后，这次会议将提供一个激动人心的环境， 学生、博士后和初级调查人员可以与世界上最优秀的人一起展示和讨论他们的研究 菲尔德。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Small Regulatory RNAs: From Bench to Bedside, organized by Drs. Frank Slack, Jörg Vogel, Ivan Martinez and Karyn Schmidt. The conference will be held in Santa Fe, New Mexico from May 1-4, 2022. RNA-based therapeutics are already approved for a variety of human diseases. A large and diverse set of small regulatory RNAs have emerged as key regulators of gene expression during development and cellular homeostasis and are frequently mis-expressed in human disease. Their small size and molecular properties make small RNAs amenable as targets and therapeutics and provide physicians with a powerful new battery of agents to diagnose and treat disease. However, while thousands of small RNAs are known, relatively little is known about their roles and targets, and there is still a limited application of these molecules in the clinic. This conference program is designed to explore the exciting biology of small regulatory RNAs and to highlight the best current research into the role that small RNAs play in fundamental processes. Additionally, other sessions will focus on the latest efforts to harness the power of these RNAs as agents in the fight against disease and provide the basic understanding that will drive the invention of powerful clinical tools. Dedicated sessions will focus on therapeutic applications of microRNA and siRNA in areas of high interest such as oncology, as well as diverse conditions ranging from rare genetic disorders to kidney disease, fibrosis, hepatitis and wound healing. It is anticipated that this conference will attract the many researchers working in small RNAs to come together to engage in critical discussions that will advance the field and accelerate the bench to bedside translation of this technology. Finally, this conference will provide a stimulating environment where students, postdocs and junior investigators can present and discuss their research with the best minds in the field.