Gut-Brain Axis

摘要 要求支持由Ann博士组织的题为“肠-脑轴”的Keystone专题讨论会会议。 作者声明：by J.会议将于3月20日至 2022年23号 肠-脑轴包括胃肠道和中枢神经系统之间的双向通信。 神经系统（CNS）。这是通过自主神经系统介导的，包括迷走神经和 肠神经系统（ENS）和内分泌、免疫和代谢途径。这些系统协调 健康和疾病的生理学和行为。其潜在的机制和途径正在被 在这一新兴的科学领域得到了阐明。了解肠-脑轴 神经生物学机制，并提供了机会，治疗中枢神经系统疾病，从外周以及 代谢和免疫疾病，包括从肥胖到非酒精性疾病的各种疾病 脂肪性肝炎到神经系统和神经精神疾病。本次会议将汇集基础和应用 来自学术界和工业界的科学家，以促进我们对肠道-大脑信号的理解。通过 强调了肠脑轴组成部分的最新研究，包括迷走神经和ENS回路 肠道激素和免疫信号，微生物组的作用，以及健康和 本次会议将促进增加兴趣，投资和跨学科合作， 推进有前途的新方法，以改善人类健康。最后，本次会议将与 Keystone Symposia会议，食欲的神经元控制。会议将分享会议，并提供 这是两个会议参与者互动和发展新合作的最佳场所， 领域的

ABSTRACT Support is requested for a Keystone Symposia conference entitled Gut-Brain Axis, organized by Drs. Ann Weber, Sarkis Mazmanian and Scott Sternson. The conference will be held in Banff, Canada from March 20- 23, 2022. The gut-brain axis encompasses bidirectional communication between the gastrointestinal tract and the central nervous system (CNS). This is mediated via the autonomic nervous system, including the vagus nerve and enteric nervous system (ENS), and endocrine, immune, and metabolic pathways. These systems coordinate physiology and behavior in health and disease. The underlying mechanisms and pathways are now being elucidated in this emerging area of scientific interest. Understanding the gut-brain axis augments neurobiological mechanisms and provides opportunities to treat CNS disorders from the periphery as well as metabolic and immunologic diseases, including diverse conditions ranging from obesity to nonalcoholic steatohepatitis to neurologic and neuropsychiatric disorders. This meeting will bring together basic and applied scientists from across academia and industry to advance our understanding of gut-brain signaling. By highlighting the latest research across the components of the gut-brain axis, including vagal and ENS circuits and gut hormone and immune signaling, the role of the microbiome, and the gut-brain axis in health and disease, this meeting will catalyze increased interest, investment and cross-disciplinary collaborations to advance promising new approaches to improving human health. Finally, this meeting is being paired with the Keystone Symposia conference, Neuronal Control of Appetite. The meetings will share sessions and provide an optimal venue for participants across both conferences to interact and develop new collaborations in these fields.