The Biology of Cytokines

描述（由申请人提供）：本提案要求支持由Christopher a . Hunter, John J. O'Shea和Fiona M. Powrie组织的题为“细胞因子生物学”的Keystone专题会议，该会议将于2012年2月5日至10日在科罗拉多州的Keystone举行。在过去十年中，细胞因子疗法已被纳入传染病和癌症治疗的标准护理，细胞因子拮抗剂已被用于慢性炎症的治疗。该领域的许多研究人员对细胞因子介导免疫系统细胞间和细胞间通讯的基本原理感兴趣。其他人感兴趣的是细胞因子和细胞因子信号对包括过敏、传染病、癌症、动脉粥样硬化和自身免疫在内的一系列疾病的发展或保护的贡献。认识到许多这些途径广泛地影响多种情况，Keystone细胞因子生物学专题会议的目标是促进研究细胞因子功能、信号转导和基因表达的分子机制的科学家与研究细胞因子如何在体内工作的科学家之间的相互作用。我们预计，这次会议将促进讨论，旨在将这些知识转化为人类疾病的新疗法。同时举行的Th17细胞在健康和疾病方面的会议将大大增加跨学科互动的机会，该会议将与本次会议分享主题演讲和两次全体会议。

DESCRIPTION (provided by applicant):This proposal requests support for a Keystone Symposia meeting entitled The Biology of Cytokines, organized by Christopher A. Hunter, John J. O'Shea and Fiona M. Powrie, which will be held in Keystone, Colorado from February 5 - 10, 2012. In the last decade cytokine therapies have been included as the standard of care for the treatment of infectious disease and cancer, and cytokine antagonists have been deployed for the management of chronic inflammation. Many researchers in this field are interested in basic principles through which cytokines mediate communication with and between cells of the immune system. Others are interested in the contributions of cytokines and cytokine signaling to the development of, or protection from, a broad range of diseases including allergy, infectious diseases, cancer, atherosclerosis, and autoimmunity. With the recognition that many of these pathways impact broadly on multiple conditions, the goal of the Keystone Symposia meeting on The Biology of Cytokines is to promote interactions between scientists who study the molecular mechanisms of cytokine function, signal transduction, and gene expression, and scientists who study how cytokines work in vivo. We anticipate that this meeting will foster discussions aimed at translating this knowledge into novel therapies for human disease. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Th17 Cells in Health and Disease, which will share a keynote address and two plenary sessions with this meeting. PUBLIC HEALTH RELEVANCE: In the last decade cytokine therapies have been included as the standard of care for the treatment of infectious disease and cancer, and cytokine antagonists have been used for the management of chronic inflammation. The goal of the Keystone Symposia meeting on The Biology of Cytokines is to promote interactions between scientists performing cutting-edge basic research studies on the molecular mechanisms of cytokine function, scientists using in vivo models to understand the biology of cytokines, and researchers working to translate this knowledge into novel therapies for human disease.