Emerging Topics in Immune System Plasticity: Cellular Networks, Metabolic Control

描述（由申请人提供）：要求支持由Steven L. Reiner, Erika L. Pearce和Yasmine Belkaid组织的题为“免疫系统可塑性新兴主题：细胞网络，代谢控制和再生”的Keystone专题会议。会议将于2013年1月15日至20日在新墨西哥州圣达菲举行。免疫系统是一个多细胞网络，能够适应外部威胁。免疫细胞与其他防御系统（如屏障）合作，在对宿主造成最小伤害的同时，选择正确的反应，防止入侵并拒绝入侵者。免疫系统的一个关键特征是其流动性和跨越时间和空间界限的能力。此外，免疫系统动力学涉及细胞扩张、临时细胞壁龛、转录改变以及分化与再生的平衡。这次会议将汇集不同的研究人员，以更好地了解免疫反应是如何精心策划的，以应对外部信息和细胞分化、功能、

Description (as provided by the applicant): Support is requested for a Keystone Symposia meeting entitled Emerging Topics in Immune System Plasticity: Cellular Networks, Metabolic Control, and Regeneration, organized by Steven L. Reiner, Erika L. Pearce and Yasmine Belkaid. The meeting will be held in Santa Fe, New Mexico from January 15 - 20, 2013. The immune system is a multi-cellular network that adapts to external threats. Immune cells cooperate with other defenses, such as barriers, to prevent breach and to reject invaders by selecting the right responses while inflicting minimal damage to the host. A key feature of the immune system is its fluidity and ability to traverse temporal and spatial boundaries. Furthermore, immune system dynamics involve cellular expansion, provisional cellular niches, altered transcription, and balancing differentiation with regeneration. This meeting will bring together diverse researchers to better understand how immune reactions are orchestrated to contend with the extrinsic information and metabolic demands of cellular differentiation, function, and homeostasis. The aims of the meeting are to 1) unveil the nature of cell-to-cell communication that occurs during different stages of the immune response, 2) reveal the latest understanding of extrinsic and intrinsic signaling networks that dictate lymphocyte and other immune cell fates, 3) increase awareness of metabolic control of immune cell fate and function, and 4) provide a format for the training and mentoring of new investigators and pre- and post- doctoral students. We anticipate that this meeting will alter the field's view of immune mobilization and execution, and will help to break barriers between immunology and other disciplines.