Enhancer Malfunction in Cancer

 描述(由申请者提供)：请求支持由Ali Shilatifard和Dale Dorsett组织的题为增强癌症中的增强器故障的Keystone研讨会。会议将于2016年1月21日至25日在新墨西哥州圣达菲举行。为什么一般转录因子的点突变与特定形式的人类恶性肿瘤相关，这一直是癌症生物学中的一个主要问题。增强子是可以转录的DNA调节元件，是发育过程中组织特异性基因表达的关键调节因子；它们通过调节元件或调节增强子-启动子通信的因子的点突变而发生故障，可能会导致发育问题。事实上，最近对癌症体细胞突变编目的全基因组研究已经确定了编码调控元件的基因间序列和特定转录因子的突变，这些转录因子在增强启动子-启动子通信中发挥作用。本次会议将回顾这方面的最新报道，并讨论增强子功能障碍在包括癌症在内的疾病发病机制和发育过程中基因表达失控的概念。同时召开的卫生和疾病中非编码RNA会议将显著增加跨学科互动的机会，该会议将与本次会议分享一次主旨演讲和两次全体会议。

 DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Enhancer Malfunction in Cancer, organized by Ali Shilatifard and Dale Dorsett. The meeting will be held in Santa Fe, New Mexico from January 21-25, 2016. Why point mutations in a general transcription factor are associated with specific forms of human malignancies has been a major question in cancer biology. Enhancers are DNA regulatory elements that can be transcribed and are key regulators of tissue-specific gene expression in development; their malfunction through point mutations in either regulatory elements or factors modulating enhancer-promoter communication could result in developmental problems. Indeed, recent genome-wide studies in the cataloging of somatic mutations in cancer have identified mutations in intergenic sequences encoding regulatory elements and in specific transcription factors that function in enhancer-promoter communication. This meeting will review recent reports in this regard and discuss the concept of enhancer malfunction in the misregulation of gene expression in disease pathogenesis, including cancer, and in development. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Noncoding RNAs in Health and Disease, which will share a keynote address and two plenary sessions with this meeting.