UC Irvine Multidisciplinary Exercise Sciences Training Program

描述（由申请人提供）：越来越多的人认识到运动和不活动在许多疾病过程中起着重要作用。这项培训补助金提案的目标是为那些对运动科学感兴趣的医学博士和博士建立一个强大而丰富的研究培训环境。该培训计划的基本纲领性主题是“综合/转化”科学。在此背景下，prgoram由两个核心组组成：分子生理学核心组和系统生理学核心组。这些核心的重点是骨骼肌，心血管和呼吸生理学，因为这些研究领域代表了计划教师的重点，并代表了广泛的持续互动领域。综合/转化方法在运动科学中尤其重要，因为现在已知身体活动在人类健康中发挥着深远的作用。博士后研究员将通过正式的教学计划，研讨会，期刊俱乐部和正在进行的研究讨论与教师和其他学员互动。在计划开始时，每个研究员将与执行委员会合作，选择一个主要和次要的研究重点，旨在反映运动科学主题的适当多样性。这些重点将从两个核心中选出。学员将熟悉各种动物和细胞模型系统以及最先进的人体性能测试方法，从而促进从这些系统到人体研究的转化，并最终转化为临床应用。对于后一个目标，加州大学人类行为实验室。Irvine GCRC/CTSC将发挥重要作用，因为它专门用于支持在优化人类研究安全和质量的环境中进行转化研究。该计划的教师有相互合作研究的历史，目前正在参与培养博士后研究员。这项拟议的培训计划旨在向博士后学员介绍新的学科，因为他们继续磨练在博士前几年掌握的技能和方法。对于博士后，该计划将吸引有兴趣成为独立调查人员的个人。运动生理学不是一个单独的ACGME认可的专业或子专业;因此，在这个程序中追求博士后培训的医学博士必须致力于学术生涯。对于博士，该计划将最适合基础科学家谁看到他们的学术生涯涉及临床相互作用，无论是通过直接的人类研究或作为医学院的成员，其中转化研究活动可能会受到鼓励。

DESCRIPTION (provided by applicant): There continues to be growing recognition that exercise and inactivity can play important roles in many disease processes. The goal of this training grant proposal is to establish a strong and rich research training environment for those M.D.s and Ph.D.s interested in exercise science. The underlying programmatic theme of this training program is that of "integrative/translational" science. Within this context, the prgoram consists of two core groups: the Molecular Physiology Core Group and the Systems Physiology Core Group. The emphasis of these cores is in skeletal muscle, cardiovascular, and respiratory physiology given that these areas of research represent the focus of the Program Faculty, and represent areas of extensive on-going interactions. An integrated/translational approach is especially important in exercise science because of the profound role that physical activity is now known to play in human health. Postdoctoral fellows will interact with the faculty and other trainees through a formal didactic program, seminars, journal clubs, and research-in-progress discussions. At the beginning of the program each fellow will work with the Executive Committee to select a primary and secondary research emphasis designed to reflect an appropriate diversity of topics in exercise science. These emphases will be selected from the two cores. Trainees will become familiar with a variety of animal and cell model systems and state-of-the-art approaches to human performance testing, thereby facilitating the translation from these systems to human research and, ultimately to clinical applications. For this latter objective, Human Performance Laboratory at the U.C. Irvine GCRC/CTSC will play an important role as it is funded specifically to support translational research in an environment that optimizes the safety and quality of human investigation. The Program Faculty have a history of collaborative research with each other and are currently involved in training postdoctoral research fellows. This proposed training program is designed to introduce postdoctoral trainees to new disciplines as they continue to hone skills and approaches mastered in the predoctoral years. For postdoctoral MD.s, the program will attract individuals seriously interested in becoming independent investigators. Exercise physiology is not a separate ACGME-recognized specialty or subspecialty; consequently, MDs pursuing postdoctoral training in this program must be committed to academic careers. For Ph.D.s, the program will be best suited for basic scientists who see their academic careers involving clinical interaction either through direct human research or as members of faculties of medical schools where translational research activity is likely to be encouraged.