Autophagy and Neurodegeneration: Mechanisms to Therapies

摘要 请求为题为自噬和神经变性的Keystone研讨会提供支持： 治疗机制，由拉尔夫·尼克松博士、安娜·玛丽亚·库尔沃博士和吉尔伯特·迪·保罗博士组织。这个 会议将于2023年3月26日至29日在犹他州雪鸟举行。 自噬是细胞动态平衡和适应压力所必需的细胞过程。 自噬功能障碍是多种人类疾病的常见致病机制，包括 神经退行性疾病。自噬领域现在已经成熟，可以支持旨在 以自噬为靶点，达到治疗目的。本次Keystone研讨会将突出该领域的 从纯粹的分子细胞生物学焦点向现在也涉及扩展的进化 特定神经退行性疾病状态的生物学功能和病因学作用。该计划还将 提供了由于行业对自噬的兴趣激增而产生的有前景的临床翻译的初步一瞥 调制作为神经退行性疾病领域的治疗方法。这个项目被设计成特别具有创新性 因为我们的目标是通过展示一个新的发现来捕捉从长凳到床边的自噬研究范围 由学术和行业演讲者组成的多学科小组，具有跨领域的概念主题组合 从神经元和神经胶质细胞自噬的基础生物学到转化医学和治疗学。欣赏 在研究界，大脑对自噬功能障碍的特殊脆弱性已经增长。另外， 在主要的神经退行性疾病中，对自噬调节有很好的治疗效果 是从临床前研究中脱颖而出的，这是一个新的概念，需要在这次会议上解决。最后，还有 正在开发两个研讨会，以解决临床翻译中的关键知识差距 自噬基础：“生物体自噬的综合调节”和“监测自噬： 生物标记物与疾病--精确度“全息”。非正式研讨会的设置将鼓励观众 参与，并为这些新兴领域提供集思广益的途径。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Autophagy and Neurodegeneration: Mechanisms to Therapies, organized by Drs. Ralph Nixon, Ana Maria Cuervo and Gilbert Di Paolo. The conference will be held in Snowbird, Utah from March 26-29, 2023. Autophagy is an essential cellular process required for cellular homeostasis and adaptation to stress. Autophagy malfunction is a common mechanism in the pathogenesis of multiple human diseases including neurodegenerative conditions. The autophagy field has now matured to support expanding initiatives aimed at targeting autophagy with therapeutic purpose. This Keystone Symposia conference will highlight the field’s evolution from an exclusively molecular cell biological focus to one that now also addresses expanding biological functions and etiological roles in specific neurodegenerative disease states. The program will also offer initial glimpses of promising clinical translation originating from surging industry interest in autophagy modulation as therapy in the field of neurodegeneration. This program is designed to be particularly innovative as the goal was to capture the bench to bedside scope of autophagy research by featuring new findings from a multidisciplinary panel of academic and industry speakers with a combination of conceptual themes spanning from basic biology of neuronal and glial autophagy to translational medicine and therapeutics. Appreciation of the brain’s special vulnerabilities to autophagy dysfunction has grown in the research community. Additionally, there are promising therapeutic responses to autophagy modulation in major neurodegenerative disorders that are emerging from preclinical studies, which is a novel concept to address at this conference. Finally, there are two workshops being developed that will address critical knowledge gaps in the clinical translation of autophagy fundamental: “Integrated Modulation of Organism Autophagy” and “Monitoring Autophagy: Biomarkers and Disease-Precision “Omics.” The informal workshop setting will encourage audience participation along with providing an avenue to brainstorm ideas in these emerging areas.