Signals and Mechanisms Underlying the Benefits of Exercise

摘要 请求支助题为《基础信号和机制》的Keystone研讨会会议 锻炼的好处，由杰弗里·霍洛维茨博士、劳里·古德伊尔博士和卡琳·埃瑟组织。这次会议 将于2023年1月14日至17日在新墨西哥州圣达菲举行。 众所周知，积极运动的生活方式是保持整体健康和幸福的关键因素；锻炼 也经常被用作治疗和/或预防许多慢性病的一线方法。尽管 支持运动对健康有益的压倒性证据，分子、细胞、组织和 作为这些有益健康影响的基础的运动的系统性反应仍不清楚。深化我们的 了解运动和健康之间的机械联系对于优化生活方式至关重要 在人的一生中改善人类健康的计划。本次Keystone研讨会将 目前的新发现解决了昼夜节律、睡眠和表观遗传学的影响，以及性别差异 运动适应性反应的差异。本次会议的各次会议还将讨论 锻炼对炎症、大脑功能/认知和不同组织之间的串扰。的总目标是 这次会议为科学家们提供了一个讨论运动的复杂反应的论坛，从而 提高我们对运动对健康的诸多益处的认识。此外，本次会议将提供 为与会者培育联系和未来潜在合作的环境。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Signals and Mechanisms Underlying the Benefits of Exercise, organized by Drs. Jeffrey Horowitz, Laurie Goodyear and Karyn Esser. The conference will be held in Santa Fe, New Mexico from January 14-17, 2023. A physically active lifestyle is known to be a key component for sustained overall health and well-being; exercise is also used often as a first-line approach for the treatment and/or prevention of many chronic diseases. Despite the overwhelming evidence supporting the health benefits of exercise, the molecular, cellular, tissue, and systemic responses to exercise that underlie these beneficial health effects remain unclear. Deepening our understanding about the mechanistic connections between exercise and health is critical for optimizing lifestyle programs to improve human health across an individual’s lifespan. This Keystone Symposia conference will present new findings addressing the impact of circadian rhythms, sleep, and epigenetics, as well as sex-specific differences on the adaptive responses to exercise. Sessions at this conference will also address the effects of exercise on inflammation, brain function/cognition, and crosstalk between different tissues. The overall goal of this conference is to provide a forum for scientists to discuss the complex responses to exercise, thereby advancing our knowledge about the many health benefits of exercise. In addition, this conference will provide an environment to foster connections and potential future collaborations for the attendees.