Mechanisms of Microbiota-Immune Interactions-Towards the Next Decade

摘要 要求为题为微生物免疫机制的Keystone专题讨论会提供支助 由Jorge Henao-Mejia博士、Eran Elinav博士和Lora Hooper博士组织。 会议将于2023年10月8日至11日在犹他州雪鸟举行。 在生命的不同阶段，宿主微生物群和免疫系统之间的相互作用在以下方面起着关键作用： 保护性免疫反应对病原体和决定疫苗和免疫疗法的效力。 此外，在哺乳动物有机体的大多数组织中，宿主微生物群组成的改变 显著地促进慢性炎症过程。然而，微生物群的机制 调节多种组织和不同生命阶段的免疫系统，在健康和疾病的背景下， 仍然基本上没有确定。本次会议将汇集该领域的领先专家，他们目前正在 开发基因组学、宏基因组学、代谢组学和成像技术的新方法， 微生物群的特定成分调节不同组织中免疫反应的机制 contexts.此外，这次会议是与流通问题的基石研讨会会议联合举行的。 代谢中间体作为燃料和信号。预计这种配对将导致新的科学 合作，开发新的技术方法，以了解潜在的 微生物群-免疫相互作用的机制，以及学术-工业相互作用的核心， 将该领域的基本机械见解转化为新的治疗方式。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Mechanisms of Microbiota-Immune Interactions-Towards the Next Decade, organized by Drs. Jorge Henao-Mejia, Eran Elinav and Lora Hooper. The conference will be held in Snowbird, Utah from October 8-11, 2023. At different stages of life, interactions between the host microbiota and the immune system play critical roles in protective immune responses against pathogens and determine the efficacy of vaccines and immunotherapies. Moreover, in most tissues of mammalian organisms, alterations in the composition of the host microbiota significantly contribute to chronic inflammatory processes. However, the mechanisms by which the microbiota regulates the immune system in multiple tissues and at different life stages, in the context of health and disease, remains largely undetermined. This conference will bring together leading experts in the field who are currently developing novel approaches in genomics, metagenomics, metabolomics and imaging technologies, to establish the mechanisms by which specific components of the microbiota regulate immune responses in different tissue contexts. In addition, this conference is being held jointly with the Keystone Symposia conference on Circulating Metabolic Intermediates as Fuels and Signals. It is anticipated that this pairing will lead to new scientific collaborations, the development of new technological approaches directed at understanding the underlying mechanisms of microbiota-immune interactions, and the nucleation of academic-industrial interactions that will translate basic mechanistic insights in the field into new therapeutic modalities.