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Estrogenicity Of Soy Formula

Estrogenicity Of Soy Formula
大豆配方奶粉的雌激素作用
批准号:
9143419
负责人:
WALTER ROGAN
金额:
$43.26万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至

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中文摘要
翻译
染料木素和大豆黄酮是大豆中的雌激素异黄酮。虽然它们的效力远不如雌二醇,但食用大豆配方奶粉的婴儿的血清浓度比雌二醇高4个数量级。我们对9个月大的婴儿进行了纵向研究,详细观察了他们的雌激素反应组织、性激素和促性腺激素的生长发育情况。我们于2014年5月完成随访,并开始数据分析。此外,我们今年报道了一种评估婴儿雌激素暴露的细胞学方法的验证。
英文摘要
Genistein and daidzein are estrogenic isoflavones found in soybeans. Although they are much less potent than estradiol, infants fed soy formula have serum concentrations that are up to 4 orders of magnitude higher than estradiol. We have been in the field with a longitudinal study of infants up to 9 months old, looking in detail at the growth and development of their estrogen-responsive tissue as well as sex hormones and gonadotropins. We completed follow-up in May, 2014, and have begun data analysis. In addition, we reported this year the validation of a cytological method for asessing estrogen exposure in infants.
期刊论文(6)
专著(0)
科研奖励(0)
会议论文
Perchlorate exposure and dose estimates in infants.
婴儿高氯酸盐暴露和剂量估计。
DOI: 10.1021/es103160j
发表时间: 2011
期刊: Environmental science & technology
影响因子: 11.4
作者: [Valentín-Blasini,Liza, Blount,BenjaminC, Otero-Santos,Samaret, Cao,Yang, Bernbaum,JudyC, Rogan,WalterJ]
通讯作者: Rogan,WalterJ
DOI: 10.1289/ehp.1306925
发表时间: 2014-05
期刊: Environmental health perspectives
影响因子: 10.4
作者: [Wang Y, Rogan WJ, Chen PC, Lien GW, Chen HY, Tseng YC, Longnecker MP, Wang SL]
通讯作者: Wang SL
DOI: 10.1097/ede.0b013e3181878645
发表时间: 2009-01
期刊: Epidemiology (Cambridge, Mass.)
影响因子: --
作者: [Chen A, Feresu SA, Fernandez C, Rogan WJ]
通讯作者: Rogan WJ
DOI: 10.1016/j.envres.2015.06.017
发表时间: 2015-10
期刊: Environmental research
影响因子: 8.3
作者: [Adgent MA, Rogan WJ]
通讯作者: Rogan WJ
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