AUTOIMMUNITY TO THE ANTERIOR UVEA IN PATIENTS WITH UVEITIS

许多形式的前葡萄膜炎被认为是由于 针对眼部抗原的自身免疫。 但一直 尚未证实涉及眼部特异性抗原 在这个过程中。 重要的是要了解 在患有前动脉炎的患者中， 葡萄膜炎 这些患者的假定炎症部位是 虹膜和睫状体。 因此我们开始寻找艾里斯 患者自身免疫性疾病的特异性蛋白质 反应 对前葡萄膜炎患者进行自体免疫筛查， 针对牛虹膜的抗体。 抗体检测 分子量约为22，000的蛋白质， 一些病人。 与对照组相比， 一般来说，比对照组个体有更高的水平， 抗体的 直到蛋白质被分离出来，T细胞反应可以 这些抗体的真正意义将是 不清楚 视网膜抗原的抗体就没有那么明显了 而不是相应的T细胞反应来区分病人 从控制。 已鉴定的蛋白质似乎 虹膜是特定的，并没有发现在其他组织的 身体 纯化该蛋白用于其他免疫学研究 正在进行

Many forms of anterior uveitis are presumed to be due to autoimmunity directed towards ocular antigens. However, there has been no confirmation that an ocular specific antigen is involved in this process. It is important to develop an understanding of the mechanisms of inflammation in patients that have anterior uveitis. The presumed site of inflammation in these patients is the iris and ciliary body. We, therefore, began to look for iris specific proteins to which patients might have an autoimmune response. Patients with anterior uveitis were screened for auto- antibodies directed against bovine iris. Antibodies were detected to a protein with a molecular weight of approximately 22,000 in some patients. When compared to a control group, patients, in general, have higher levels than control individuals of this antibody. Until the protein is isolated and T-cell responses can be measured, the true significance of these antibodies will be unclear. Antibodies to retinal antigens are much less revealing than the corresponding T-cell responses in distinguishing patients from controls. The protein that has been identified appears to be specific to the iris and is not found in other tissues of the body. Purification of this protein for other immunologic studies is in progress.