EXPRESSION OF CLASS II ANTIGENS IN OCULAR INFLAMMATORY DISORDERS

检测眼部非淋巴样细胞表面II类抗原的表达 免疫过氧化物酶在实验性自身免疫性葡萄膜视网膜炎中的作用 技术。未检测到非淋巴样细胞上的II类抗原 正常大鼠。然而，在视网膜色素上检测到了这些抗原 上皮细胞和睫状体上皮细胞在发育前几天 临床和组织病理学EAU。视网膜上发现了IA抗原 视网膜细胞开始浸润时的血管内皮细胞， 术后出现在角膜基质细胞和巩膜成纤维细胞上。 临床早期EAU。 研究表明，在EAU过程中，眼部非淋巴组织 细胞可以被激活以表达II类抗原。这种抗原 表达可能在免疫的启动和持续中起重要作用 眼睛的反应性。

Expression of class II antigens on ocular nonlymphoid cells was evaluated in experimental autoimmune uveoretinitis (EAU) by the immunoperoxidase technique. Class II antigens on nonlymphoid cells were not detected from normal rats. However, these antigens were detected on the retinal pigment epithelia and ciliary body epithelia a few days prior to the development of clinical and histopathological EAU. Ia antigen was noted on the retinal vascular endothelia at the onset of cellular infiltration in the retina, and appeared on the corneal keratocytes and scleral fibroblasts after the early stage of clinical EAU. The study demonstrates that during the course of EAU the ocular nonlymphoid cells can be activated to express class II antigens. This antigen expression may be important in the initiation and perpetuation of immune reactivity in the eye.