Ultrasensitive InN nanowire biosensors for real time, label free detection of polymorphic DNA sequences in living systems

超灵敏 InN 纳米线生物传感器，用于实时、无标记检测生命系统中的多态性 DNA 序列

• 批准号: 381527-2009
• 负责人: Mi, Zetian
• 金额: $ 9.94万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Strategic Projects - Group
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=484948
• 关键词: Ultrasensitive; InN; nanowire; biosensors; real

There has been escalating interest, both in research and commercial fields, for the development of highly sensitive, selective, robust, and portable DNA sensors to attend the growing market of molecular diagnostics. In particular, there is an urgent need for clinical devices to genotype polymorphic DNA sequences, which, through interaction with various environment factors, are largely responsible for the development and progression of common diseases, including diabetes, heart diseases, cancer, depression and asthma. In this strategic project, we propose to develop, for the first time, a novel InN nanowire based nanotechnology platform for ultrasensitive, real time, label free, and multiplexed detection of DNA sequences, with a strong

无论是在研究领域还是商业领域，人们对开发高灵敏度、高选择性、高可靠性和便携式DNA传感器的兴趣都在不断上升，以满足分子诊断市场的不断增长。尤其迫切需要临床设备对多态DNA序列进行基因分型，多态DNA序列通过与各种环境因素的相互作用，在很大程度上负责常见疾病的发生和进展，包括糖尿病、心脏病、癌症、抑郁症和哮喘。在这个战略项目中，我们首次提出开发一种新颖的基于纳米线的纳米技术平台，用于超灵敏、实时、无标签和多路检测DNA序列，具有强大的