Metastasis

摘要 请求为琼博士组织的题为“转移”的Keystone专题讨论会提供支助。 Massagué，Sean莫里森和Caroline Dive。会议将在不列颠哥伦比亚省的温哥华举行 加拿大，2023年5月7日至10日。 大多数癌症死亡是由远处转移引起的，但调节远处转移的机制是 不太了解。转移是一个非常低效的过程，其中很少有播散的癌细胞存活， 甚至更少的扩散，但很少有人知道为什么。本次会议将讨论转移的性质 起始细胞以及它们的表型可塑性、遗传和表观遗传进化。演讲者将涵盖 主题包括循环癌细胞的特征以及成像和DNA的最新进展 分析有助于转移的临床管理。其他会议将涵盖为什么癌细胞 有时转移后会休眠此外，该计划将包括会议，将讨论 转移的代谢调节以及代谢环境如何影响癌细胞的存活 在转移过程中。最后，本次会议将与Keystone研讨会会议配对， 耐药肿瘤微环境。将举行联席会议，两个会议的与会者将 能够在用餐时间和海报会议期间进行互动和网络。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Metastasis, organized by Drs. Joan Massagué, Sean Morrison and Caroline Dive. The conference will be held in Vancouver, British Columbia Canada from May 7- 10, 2023. Most cancer deaths are caused by distant metastasis, yet the mechanisms that regulate distant metastasis are poorly understood. Metastasis is a very inefficient process in which few disseminated cancer cells survive, and even fewer proliferate, but little is known about why. This conference will address the nature of metastasis initiating cells as well as their phenotypic plasticity, genetic and epigenetic evolution. Speakers will cover topics including the characterization of circulating cancer cells and how recent advances in imaging and DNA analysis are assisting the clinical management of metastasis. Other sessions will cover why cancer cells sometimes go dormant after metastasis. Additionally, the program will include sessions which will discuss the metabolic regulation of metastasis and how the metabolic environment influences the survival of cancer cells during metastasis. Finally, this conference is being paired with the Keystone Symposia conference entitled, The Resistant Tumor Microenvironment. There will be joint sessions and attendees of both conferences will be able to interact and network during mealtimes and poster sessions.